The following news items are related to the research Cancer development and immune defense.
Front cover Human Mutation21 August 2019
The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,
Awarded KWF grants for Radboudumc researchers2 July 2019
The Dutch Cancer Society (KWF) has awarded 25.5 million euros to 50 new research projects in 16 different institutes. 8 grants are awarded to Radboudumc researchers. We congratulate our researchers with this funding and wish them success with their great work.
New opportunity for Henk Stunnenberg24 June 2019
After more than 22 years, Henk Stunnenberg, theme Cancer development and immune defense, has left the Radboud University, Dept. of Molecular Biology, to take up a position at the Prinses Maxima Centre for pediatric oncology in Utrecht. On Friday 5 July a farewell drink is being organized.
Studying the function of liver cancer genes in mini-organs24 May 2019
Michiel Vermeulen, theme Cancer development and immune defense, and colleagues, have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Their results were published in the scientific journal Cell Stem Cell.
Three VIDI grants for RIMLS researchers24 May 2019
Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.
A cozy relationship; the enhancer landscape of embryonic stem cells13 May 2019
In Nature Cell Biology, Yaser Atlasi, Wout Megchelenbrink and colleagues from the group of Henk Stunnenberg, theme Cancer development and immune defense, published a combination of experimental and bioinformatic approaches to study enhancer regulation in different states of embryonic stem cells.
Size matters: Miniaturised interaction proteomics with ultra-low input requirements4 April 2019
Cristina Furlan and René Dirks from the groups of Michiel Vermeulen and Hendrik Marks, theme Cancer development and immune defense, teamed up to develop a low-input interaction proteomics platform, called on-chip AP-MS. They published these findings in Nature Communications.
A personal touch of Glenn van Wigcheren4 April 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Glenn van Wigcheren.
A personal touch of Georgina Flórez Grau10 March 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Georgina Flórez Grau.
Imprinted genes during early embryonic development18 February 2019
René Dirks, with other members from the lab of Hendrik Marks, theme Cancer development and immune defense, show in a paper in Epigenetics & Chromatin that genomic imprinting (genes expressed from the paternal or maternal allele only) is often lost in cultured embryonic stem cells.
Five RIMLS researchers in top 1 percent by citations13 December 2018
Bas Dutilh, Leo Joosten, Jos van der Meer, Mihai Netea and Henk Stunnenberg made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
Genome protection during early embryonic development22 November 2018
In Cell Stem Cell, Guido van Mierlo with other members from the lab of Hendrik Marks, theme Cancer development and immune defense, show how the cells of the embryo are getting prepared to form the various cell types that are present in an organism, such as skin cells or heart cells.
Connecting splicing and epigenetics in skin stem-cells20 November 2018
Sabine Tanis and Klaas Mulder, theme Cancer develoment and immune defense, found that part of this robustness is conferred by functional connections between transcriptional/epigenetic and splicing regulation of genes involved in cell-cell contacts. Their findings are published in Cell reports.
Cancer cell moves like a predator Lévy walk may be the weak spot of cancer cells19 November 2018
In contrast to their non-metastatic counterparts, metastatic cancer cells show movement patterns that are also often employed by predators searching for prey. This was shown by an international study on movement patterns of cancer cells published in Nature Communications.
Report of the 12th New Frontiers symposium Big data, better healthcare? - 1 November 20187 November 2018
Examples from the application of deep learning to image reading in pathology and radiology and the application of network medicine to monitor infectious disease outbreaks or collective mood states using twitter data showed the huge potential of big data approaches for building better healthcare.
Report of the 12th New Frontiers symposium Better care, network care? - 2 November 20187 November 2018
No easy answers at this symposium last Friday, only challenges that can be overcome if we succeed in 5 things. First and most radically, put patients in the center of healthcare. Second, start with assessing what the local population needs and not what local professionals have to offer.
Regulating gene expression during cellular differentiation: a NuRDy affair2 November 2018
Researchers from the Michiel Vermeulen lab used genome-wide profiling and quantitative interaction proteomics to study the dynamics of the NuRD complex during differentiation from mouse embryonic stem cells into neural progenitor cells. They published their findings in Nature Communications.
A personal touch of Maaike van Bergen9 October 2018
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Maaike van Bergen.