New test for Lyme disease is not reliable15 June 2022
To determine whether someone has Lyme disease, doctors in the Netherlands often use antibody tests. For some time now, so-called cellular tests have been available on the market. However, the VICTORY study published in The Lancet Infectious Diseases has found that these tests are not reliable.
Field research on malaria vaccine offers unexpected surprise23 May 2022
Field research on the effectiveness of a malaria vaccine, came up with unexpected results for an international group of researchers including Benjamin Mordmüller of Radboudumc. The vaccine evokes a broader response against malaria proteins than there are in the vaccine.
Neolithic made us taller and more intelligent, but more prone to heart disease How modern European populations have evolved over the past 50,000 years6 April 2022
After the Neolithic, European populations showed an increase in height and intelligence, reduced skin pigmentation and increased risk of cardiovascular disease due to genetic changes that lowered concentrations of 'good' HDL cholesterol.
With concerted effort, tuberculosis could be eradicated in 30 years time March 24th was World Tuberculosis Day24 March 2022
Since 2020, the number of deaths from tuberculosis increased for the first time in a decade, caused by the COVID pandemic: fewer people had access to the right care on time. Some catching up is needed.
Immunogenetic studies in diverse populations are essential Clear immunological differences between populations in Europe and Africa15 February 2022
Genetic factors that partly determine host defenses sometimes differ significantly between people and populations. This is shown in a publication in the American Journal of Human Genetics by researchers from the Netherlands, Tanzania and India.
What does the shingles vaccine teach us about other vaccines? Investigating the role of trained immunity27 January 2022
The vaccine for shingles, a condition that causes itching, pain, and blisters, is 90% effective, even in elderly. This is remarkable, since most vaccines offer less protection in elderly. Radboudumc is investigating why this vaccine works so well and how it might help us to develop better vaccines.
Laurens Verscheijden awarded doctorate degree 'cum laude'19 January 2022
Laurens Verscheijden of the Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation.
Novel high-resolution targeted sequencing of the cervicovaginal microbiome published in the Journal of BMC Biology28 December 2021
This project of William Melchers, Karolina Andralojc and Mariano Molina describe a novel sequencing method to profile the cervicovaginal microbiome at the species level and with the potential to elucidate the role of the microbiome in hrHPV-induced carcinogenesis.
What can we learn from rural Tanzanian food?23 December 2021
What we eat affects our bodies. A diet high in plant based products and low in fat offers health benefits and prevents lifestyle diseases, such as cardiovascular disease. This is what Quirijn de Mast shows based on his research in Africa.
Maarten Jansen wins Kennis Connectors Global Health award16 December 2021
In the category of PhD dissertations, Maarten Jansen won the Knowledge Connectors Global Health Award. Maarten studied how various countries (re)consider the composition of their basic health care package and how citizens can be given a role in this.
The European Hector Research Award in HIV 2021 awarded to Angela Colbers and David Burger2 November 2021
On Friday 29 October 2021, during the 18th European AIDS Conference in London, the Hector Research Award for the best scientific article related to clinical or epidemiological HIV research was presented to Angela Colbers and David Burger, both working in the Pharmacy of the RadboudUMC.
How healthy is James Bond? - A flu to a kill No time to die: the pathogens surrounding secret agent 00721 October 2021
James Bond made a total of 25 films between 1962 and 2021. In all those films, secret agent 007 washed his hands only twice, even though he often stayed in not so hygienic places with considerable health risks. Radboudumc researchers examined all the health risks in the 47 countries Bond visited.
Unraveling piRNA-mediated degradation of viral RNA in vector mosquitoes published in Nucleic Acids Research1 September 2021
Joep Joosten and colleagues have published their discoveries about a new molecular mechanism with important implications for our understanding of the mosquito immune system and its role in controlling transmission of viruses.
Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum in Nature Communcations1 July 2021
Using complexome profiling Felix Evers, Taco Kooij and colleagues unravel the composition of mitochondrial oxidative phosphorylation complexes of asexual and sexual blood-stage malaria parasites, showing abundance differences and a metabolic switch central to gametocyte development and function.
Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses2 June 2021
Rosanne van Deuren published her study in Genome Medicine which shows that functionally grouping common and rare genetic variants enables the elucidation IL-1-mediated biological mechanisms, specifically, for IL-1β and IL-6 cytokine responses induced by various stimuli.
Anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity14 April 2021
Cell reports publication by Charles Dinarello and Mihai Netea and colleagues, theme Infectious diseases and global health, shows that the anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection17 February 2021
In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.
ZonMw grants to study optimal use of COVID-19 vaccines in patients with impaired immune systems3 February 2021
How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Our researchers received grants from ZonMw to make these studies possible.
Rob Aarnoutse is appointed as professor in Translation pharmacology of antimicrobial agents in particular drugs for tuberculosis25 January 2021
Hospital pharmacist and clinical pharmacologist Rob Aarnoutse is appointed as professor in ‘Translation pharmacology of antimicrobial agents, in particular drugs for tuberculosis’ at Radboud University / Radboudumc, starting 16 November 2020.