Research theme Nanomedicine


Nanomedicine About theme

The nanomedicine research theme aims to study, design, synthesize and characterize molecules and molecular assemblies in order to elucidate the structure and function of biological systems and to unravel the molecular basis of disease.

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Nanomedicine About theme

Nanomedicine is a rapidly developing area of research that aims to create functional units on the nanoscale to manipulate cellular processes for use in research and biomedicine. Understanding the functioning of living cells, particularly those processes that cause disease, requires a detailed molecular understanding of the biological processes that govern cellular behavior. This includes the analysis of omics data and the detailed study of molecular interactions, both inter- and intracellularly, with molecular probes that minimally affect the processes to be analyzed. Improved understanding, furthermore, will lead to better methods for amending biological processes that have become dysfunctional, and, hence, to the development of novel medicines.
 
Such an approach can only succeed in close collaboration between researchers in chemistry, biology and biomedicine with an affinity for molecular life sciences. The nanomedicine research theme thus encompasses a multidisciplinary research platform. It aims to study, design, synthesize and characterize molecules and molecular assemblies in order to elucidate the structure and function of biological systems and to unravel the molecular basis of disease. It seeks to translate improved understanding into novel and more effective diagnostics and therapeutics.

Objectives

  • We aim to develop molecular probes and bio-orthogonal chemistry to label biomolecules in living cells with minimal invasiveness and optimal selectivity. Using state-of-the-art imaging methodologies, we study the fate of biomolecules in living cells and organisms.
  • We study protein signaling pathways at the molecular level in living cells.
  • We study mechanisms and approaches for cellular drug delivery.
  • We will investigate the dynamic interactions of cells with their environment/extracellular matrix.
  • We will identify and characterize molecular markers for disease associated dysfunctional biological processes and develop methods for their detection.
  • We will develop microfluidics platforms to study single-cell behavior in detail.
  • We aim to develop bio- and chemo-informatics tools to analyze big data generated by omics platforms more effectively.
  • We will develop targeted nanosized carrier systems for cargo transport, delivery and immune regulation.
  • We seek to bring chemists, biologists and medical doctors together to create an open research environment in which medical challenges are translated into nanomedicine solutions.

Theme leader

Daniela Wilson PhD
+31 (0)24 365 21 85
associate professor

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Researchers Nanomedicine

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Our research Nanomedicine

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Research group leaders


Answers in Dutch

Information on our research can also be found in Dutch on the Nationale Wetenschapsagenda website. The information here answers questions asked by Dutch citizens.

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