20 August 2018

In a recent publication in Biomaterials, a multidisciplinary team from Radboudumc (Dentistry; theme Reconstructive and regenerative medicine), Radboud University (Molecular Materials), and the Association of Dutch Burn Centres present their first results with a recently developed thermogel for use in wound repair.

Changing wound dressings inflicts pain and may disrupt wound repair. Novel synthetic thermosensitive hydrogels based on polyisocyanopeptide (PIC) offer a solution. These gels are liquid below 16 °C and form gels beyond room temperature. The architecture and mechanical properties of PIC gels closely resemble collagen and fibrin, including the characteristic stiffening response at high strains. In a full-thickness dorsal skin wound model in mice wounds were treated with PIC gel and PIC-RGD gel for 3 and 7 days and analyzed. The absence of adverse effects, ease of application, and the possibilities for bio-functionalization make the biomimetic PIC hydrogels suitable for development into wound dressings. Since we aim to bring this material to the patient setting, we closely collaborate with the Dutch burns foundation and Dutch burn centres. We hope to soon present additional data that further demonstrate the usefulness of this novel thermogel. 


Op 't Veld RC, van den Boomen OI, Lundvig DMS, Bronkhorst EM, Kouwer PHJ, Jansen JA, Middelkoop E, Von den Hoff JW, Rowan AE, Wagener FADTG* Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair. Biomaterials.

Related news items

NWO grant to develop new biomaterials for Sander Leeuwenburgh and Roland Brock

20 August 2019

Sander Leeuwenburgh (Dept. of Dentistry) and Roland Brock (Biochemistry) were recently awarded with a grant of 581 k€ by the Netherlands Organisation for Scientific Research (NWO, Domain Applied & Engineering Sciences AES) to develop new biomaterials for improved regeneration of bone defects.

read more

European Commission Initiative on Breast Cancer (ECIBC) Guidelines

13 August 2019

In Annals of internal medicine Mireille Broeders and colleagues from the ECIBC Guidelines Development Group described the methods used to develop person-centered evidence-based recommendations for screening and diagnosis of breast cancer.

read more

Circulation publication for exercise physiologists

13 August 2019

Thijs Eijsvogels and Vincent Aengevaeren showed that exercise-incuded elevations of troponin concentrations are predictive of major adverse cardiovascular events and mortality.

read more

DELA, Radboudumc and Games for Health start a new project to fight loneliness among elderly using games

12 August 2019

More than half of people aged 75 and over feel their selves lonely every now and then. A special collaboration between DELA, Radboudumc, and Games for Health will investigate whether joined gaming between elderly and young people can alleviate this social problem.

read more

Floris Schreuder received Dekker grant

6 August 2019

Floris Schreuder received one of the ten Dekker grants from the Dutch Heart Foundation (Hartstichting).

read more

A warm welcome for a new RIMLS colleague Nico Sommerdijk

5 August 2019

As of 1 August we welcome Nico Sommerdijk as our new colleague at the RIMLS. Nico will join the department of Biochemistry, with his research group “Biochemistry of Mineralized Tissues”.

read more