Tumors of the digestive tract About themeOur mission is to arrive at an optimal classification of patients to improve surveillance, diagnosis, treatment, and outcome for patients with cancer of the digestive tract.
In our theme, we are committed to improving outcome for patients with cancer of the digestive tract. To this end, we aim our research at selecting patients for their personalized trajectory. We use basic, translational, and clinical research to provide the evidence for this trajectory. This involves surveillance and early detection, optimal diagnosis including molecular analyses and innovative imaging, and innovation in treatment, ranging from improved surgical techniques to immunotherapy.
- We will identify new genes responsible for hereditary colorectal cancer syndromes.
- We will develop strategies for improving detection of hereditary forms of pancreatic cancer.
- We aim to prevent cancer in high-risk patients using vaccination and lifestyle interventions.
- We will develop new molecular diagnostic tools to predict tumor response to therapy.
- We will identify relevant biomarkers for the development of metastatic disease and implement these factors in daily practice.
- We will develop surgical techniques to optimize patient care.
Lines of research
Discovery of novel genetic and exposure factorsThis includes both fundamental research, focusing on intestinal microbiota that drive hereditary cancer, as well as improvement of identification and stratification of patients who develop cancer as a result of these cancer syndromes, as has been successfully achieved for Lynch syndrome patients.
Evidence-based pathologyDetection, validation, and implementation of new and classic biomarkers in the different patient cohorts have direct effect on treatment of patients. This topic together with the previous research line come together in the Laboratory for tumor genetics, where patient care is combined with biomarker research.
News & agendas
Research on improved irradiation of liver tumors from withinNWO grant for public-private partnership25 August 2020
Universal Tumor DNA BRCA1/2 Testing of Ovarian CancerPrescreening PARPi Treatment and Genetic Predisposition20 August 2020
Increased role of patients after bowel cancer treatment30 July 2020
- Lynch syndrome from basic research to implementation in daily clinical practice
- Microbiome: from association studies towards clinically relevant tools
- Evidence-based pathology: guiding personalized treatment
- Imaging: getting ready for the next challenges
- Surgery: improved outcomes due to improved care
- Epidemiology: Study of variation to improve future care
Centers of clinical expertise
Information might be only available in Dutch.