11 January 2019

Neutrophils can produce Neutrophil Extracellular Traps (NETs), which are web-like structures consisting of chromatin aimed to capture pathogens. NETs appear to play a role in several diseases including rheumatic autoimmune diseases. Although NET formation was originally described as a NADPH oxidase (NOX)-dependent pathway, it appears that there are also NOX-independent pathways of NET release. Currently, no tools are available that can discriminate between different NET-forming pathways.

Johan van der Vlag, theme Renal disorders, and colleagues, developed a novel method that allows the discrimination of NETs generated through NOX-dependent or NOX-independent pathways. Using this novel NET assay they showed the presence of different types of NETs in the blood of patients with various diseases.

Furthermore, they showed that NOX-dependent and NOX-independent NETs differ in their endothelial cell stimulatory capacity. These results indicate heterogeneity in NET-forming pathways in vivo and highlight the need for disease-specific strategies to prevent NET-mediated pathology.Their findings were recently published in Annals of the Rheumatic Diseases, the highest ranking journal in the field of Rheumatology.

Related news items


Radium 223-mediated zonal cytotoxicity of prostate cancer in bone

21 January 2019

In preclinical prostate carcinoma in the bone, Rad-223 eradicated effectively micro-tumors but macro-tumors persisted and expanded. The data point to application of Rad-223 in secondary prevention of early bone-metastatic disease and regimens co-targeting the tumor core.

read more

COPAL reveals remodeling of mitochondrial protein complexes in Barth syndrome

21 January 2019

Martijn Huijnen, theme Mitochondrial diseases, and colleagues developed COmplexome Profiling ALignment (COPAL) to systematically asses the effect of Barth syndome on mitochondrial protein complexes. They published their findings in Bioinformatics.

read more

Two papers on molecular mechanisms of GFI1B in inherited bleeding syndromes in Haematologica

21 January 2019

Rinske van Oorschot from the Van der Reijden group, theme Cancer development and immune defense, has published two papers on the transcription factor GFI1B in Haematologica.

read more

LEO Foundation grant for Ellen van den Bogaard and Patrick Zeeuwen

17 January 2019

LEO Foundation ‘Open competition grants’ are given to support the best dermatology research projects worldwide that improve the understanding of the underlying medicinal, biological, chemical, or pharmacological mechanisms of dermatological diseases and their symptoms.

read more

RIMLS awards festival Twelve winners

16 January 2019

In 5 categories RIMLS young researchers received an award and bonus during the New Year's drinks. See all photo's.

read more

RIMLS award for Bert van der Reijden

16 January 2019

Bert van der Reijden, theme Cancer development and immune defense, received the RIMLS award 2018 for his long-lasting and dedicated commitment to the RIMLS Graduate School.

read more
  • Go to