11 January 2019

Neutrophils can produce Neutrophil Extracellular Traps (NETs), which are web-like structures consisting of chromatin aimed to capture pathogens. NETs appear to play a role in several diseases including rheumatic autoimmune diseases. Although NET formation was originally described as a NADPH oxidase (NOX)-dependent pathway, it appears that there are also NOX-independent pathways of NET release. Currently, no tools are available that can discriminate between different NET-forming pathways.

Johan van der Vlag, theme Renal disorders, and colleagues, developed a novel method that allows the discrimination of NETs generated through NOX-dependent or NOX-independent pathways. Using this novel NET assay they showed the presence of different types of NETs in the blood of patients with various diseases.

Furthermore, they showed that NOX-dependent and NOX-independent NETs differ in their endothelial cell stimulatory capacity. These results indicate heterogeneity in NET-forming pathways in vivo and highlight the need for disease-specific strategies to prevent NET-mediated pathology.Their findings were recently published in Annals of the Rheumatic Diseases, the highest ranking journal in the field of Rheumatology.

Related news items

Martinus van Marum prize call for proposals

14 November 2019

The Martinus van Marum prize is given to young researchers (<5 years after PhD) for the original research they have conducted in science and technology.

read more

New NFU eBROK® course open for registration

1 November 2019

This platform is not only for researchers who want to obtain their BROK® certificate, but also for researchers who already have a BROK® certificate and want to keep their certification (re-certification).

read more

A personal touch of Marlies Cornelissen

31 October 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Marlies Cornelissen.

read more

Collective cancer invasion forms an integrin-dependent radioresistant niche

29 October 2019

Anna Häger and Peter Friedl, theme Cancer development and immune defense, identified a new niche of cancer cell survival and developed an integrin inhibition therapy to overcome resistance. They have published their results in JEM.

read more

Algorithm to predict which cancer patients benefit from immunotherapy

29 October 2019

Rik Lindeboom and Michiel Vermeulen, theme Cancer development and immune defense, have developed an algorithm that can predict which cancer patients are more likely to benefit from immunotherapy. This new technology’s potential is described in Nature Genetics.

read more

X² Ambition Award for Sandra Heskamp

28 October 2019

This award is intended for 'coming women’: young, ambitious women at a stage of their careers where they make important career choices. This prize is especially for women who show exemplary behaviour within the organization where they work, but also outside their organization.

read more