22 March 2019

Mangala Srinivas, theme Nanomedicine, showed in Advanced Functional Materials that nano‐particles (radius 100 nm), are suitable for long‐term in vivo ultrasound in combination with 19F MRI and fluorescence.

Publication: link.
Mangala Srinivas

Ultrasound is the most commonly used clinical imaging modality. However, in applications requiring cell‐labeling, the large size and short active lifetime of ultrasound contrast agents limit their longitudinal use. Here, 100 nm radius, clinically applicable, polymeric nanoparticles containing a liquid perfluorocarbon, which enhance ultrasound contrast during repeated ultrasound imaging over the course of at least 48 h, are described. The perfluorocarbon enables monitoring the nanoparticles with quantitative 19F magnetic resonance imaging, making these particles effective multimodal imaging agents. Unlike typical core–shell perfluorocarbon‐based ultrasound contrast agents, these nanoparticles have an atypical fractal internal structure. The nonvaporizing highly hydrophobic perfluorocarbon forms multiple cores within the polymeric matrix and is, surprisingly, hydrated with water, as determined from small‐angle neutron scattering and nuclear magnetic resonance spectroscopy. Finally, the nanoparticles are used to image therapeutic dendritic cells with ultrasound in vivo, as well as with 19F MRI and fluorescence imaging, demonstrating their potential for long‐term in vivo multimodal imaging.

Related news items


The ICI Amsterdam-Leiden-Nijmegen cancer vaccine consortium

7 April 2020

The Chemical Immunology group from Martijn Verdoes, theme Nanomedicine, joined forces with two Organic Chemistry groups and a Chemical Biology group from Leiden University, and Immunology groups at the AmsterdamUMC and the LUMC to form a consortium to develop new cancer vaccines.

read more

Three VIDI grants for RIMLS researchers

24 May 2019

Matthijs Jore, Daniele Tauriello and Johannes Textor are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.

read more

ERC Proof of Concept grant for Mangala Srinivas

2 May 2019

Mangala Srinivas, theme Nanomedicine, received an ERC Proof of Concept grant 2019-1 for her project entitled: 'Ex vivo cell labeling for in vivo imaging applied to cell therapy'.

read more

RIMLS awards festival Twelve winners

16 January 2019

In 5 categories RIMLS young researchers received an award and bonus during the New Year's drinks. See all photo's.

read more

Rare immune cells kickstart anti-cancer immune response

3 September 2018

Florian Wimmers, theme Cancer development and immune defense, and colleagues developed a high-throughput nano lab to shed light on this process. Their findings were published in Nature Communications.

read more

ERA-NET grant on imaging in cardiovascular disease

3 November 2017

Subclinical atherosclerosis characterization: Nanoparticle-based molecular and cellular imaging (SCAN).

read more