The board of the Dutch Research Council (NWO) Domain Science has approved sixteen proposals in the Science-KLEIN Open Competition.
The topics vary from research into the functions of proteins in the cell walls of the tuberculosis bacterium to research into the use of light to build fast computers. KLEIN grants are intended for innovative, high-quality, fundamental research and/or studies involving matters of scientific urgency.
Topic: Molecular mechanisms of actin isoform usage in cancer cell migration
Koen van den Dries, theme Nanomedicine
Metastases occur when cancer cells move from the original tumour to another tissue. Although we know that metastases are caused by the mobility of cancer cells, ways to prevent metastases are limited. More knowledge is therefore needed about the means by which cancer cells move. The movement of cancer cells is regulated by their skeletons and this project will investigate the role small differences in the building blocks of this skeleton play in the movement of cancer cells. We expect better definition of these differences to lead to more options for preventing metastases in the future.
Topic: Synthetic affinity-based probes for proteome-wide identification of poly(ADP-ribosyl)-binding proteins
Michiel Vermeulen, theme Cancer development and immune defence (RIMLS-faculty of science) and Dmitri Filippov (Leiden University)
Adenosine diphosphate ribosylation is a common post-translational protein modification that is involved in various pathological processes such as cancer, age-related diseases and viral infections. It is important that we know what proteins can interact with adenosine diphosphate ribose chains if we are to design better medicines. In this study, different molecules that contain adenosine diphosphate ribose will be synthesized and subsequently used for interaction tests in extracts from human cells. Follow-up tests will also be carried out to identify proteins that bind with adenosine diphosphate ribose and that play a role in the cellular response to damage to DNA.
Related news items
BRAINMODEL: precision medicine for brain disorders25 October 2021
A team of researchers from Radboudumc, VU Amsterdam and other institutes is going to look for new and better ways to heal developmental disorders in the brain.read more
How healthy is James Bond? - A flu to a kill No time to die: the pathogens surrounding secret agent 00721 October 2021
James Bond made a total of 25 films between 1962 and 2021. In all those films, secret agent 007 washed his hands only twice, even though he often stayed in not so hygienic places with considerable health risks. Radboudumc researchers examined all the health risks in the 47 countries Bond visited.read more
Surprisingly dominant cause underlying type I congenital defect of glycosylation21 October 2021
Alex Garanto, Melissa Bärenfänger, Mirian Janssen, and Dirk Lefeber published a new study, identifying a surprisingly dominant genetic cause underlying type I congenital defect of glycosylation with neuromusculoskeletal phenotypes.read more
Sensitive blood-test as a patient-friendly alternative for bone marrow-based cancer monitoring20 October 2021
Hans Jacobs and Pieter Langerhorst, theme Cancer development and immune defense, and colleagues are one step closer to implementation of personalized diagnostics for bone marrow-based cancer monitoring.read more
Register for peer coaching for RIMLS PhD candidates20 October 2021
As a PhD candidate, you are in the lead of your own learning process, but you don’t need to do this alone. Register for the peer-coaching group ‘Stay in the lead – Together’ before 11 November 2021.read more