11 February 2021

The Marie Sklodowska-Curie fellowships are very prestigious awards from the European Commission.They support researchers at all stages of their careers, regardless of age and nationality. The MSCA also support cooperation between industry and academia and innovative training to enhance employability and career development.

Juan Pablo Rigalli, theme Renal disorders, is awarded with a Marie Curie Fellowship from the European Commission to study the application of extracellular vesicles in precision pharmacotherapy. 

Extracellular vesicles are nanoparticles released by almost every cell of the organism. They are easily accessible, for example in urine and blood, and provide useful information about the cells of origin. In the frame of this project, which will be executed at Heidelberg University Hospital (Germany), Juan will investigate the application of extracellular vesicles to estimate the drug clearance capacity of different tissues.

In general, drugs are prescribed based on average parameters from a population. However, individuals may exhibit enormous differences in their drug clearance. This could lead to the lack of therapeutic efficacy or toxicity. For some particular therapeutic agents, life threatening situations may occur due to underdosing or overdosing. Hereby, extracellular vesicles will be investigated as a potential tool to assist the physicians in providing a treatment fitted to each individual patient.

The fellowship is a Standard European Fellowship to move to Heidelberg University Hospital in Germany. In the past years, Juan and his colleagues in renal physiology (Department of Physiology) have investigated extracellular vesicles. Joost Hoenderop and Juan will continue an active collaboration to further develop this line of research.

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