NL
DE
The Marie Sklodowska-Curie fellowships are very prestigious awards from the European Commission.They support researchers at all stages of their careers, regardless of age and nationality. The MSCA also support cooperation between industry and academia and innovative training to enhance employability and career development.
Juan Pablo Rigalli, theme Renal disorders, is awarded with a Marie Curie Fellowship from the European Commission to study the application of extracellular vesicles in precision pharmacotherapy.
Extracellular vesicles are nanoparticles released by almost every cell of the organism. They are easily accessible, for example in urine and blood, and provide useful information about the cells of origin. In the frame of this project, which will be executed at Heidelberg University Hospital (Germany), Juan will investigate the application of extracellular vesicles to estimate the drug clearance capacity of different tissues.
In general, drugs are prescribed based on average parameters from a population. However, individuals may exhibit enormous differences in their drug clearance. This could lead to the lack of therapeutic efficacy or toxicity. For some particular therapeutic agents, life threatening situations may occur due to underdosing or overdosing. Hereby, extracellular vesicles will be investigated as a potential tool to assist the physicians in providing a treatment fitted to each individual patient.
The fellowship is a Standard European Fellowship to move to Heidelberg University Hospital in Germany. In the past years, Juan and his colleagues in renal physiology (Department of Physiology) have investigated extracellular vesicles. Joost Hoenderop and Juan will continue an active collaboration to further develop this line of research.
Related news items
Grants for heart and kidney research Two awards to Radboudumc in Open Competition ENW-XS
21 July 2022Two researchers from the Radboudumc receive a grant from the NWO within the Open Competition of the Exact and Natural Sciences. They are Thijs Eijsvogels, who studies the heart, and Pieter Leermakers, who studies the kidneys.
read more
Grants for research on magnesium deficiency and malaria Vidis for Felix Hol and Jeroen de Baaij
1 July 2022 Radboudumc researchers Jeroen de Baaij and Felix Hol both receive an NWO Vidi grant for their research, respectively on magnesium deficiency in type 2 diabetes and on malaria. read more
Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling
11 May 2022 Bart Smeets, Jitske Jansen and collegues, theme Renal disorders published this article in the Human Development. read more
ERC Starting Grant awarded to Jeroen de Baaij
17 March 2022 Jeroen de Baaij, kidney researcher the Radboudumc, receives an ERC Starting Grant worth 1.5 million euros. He will use this grant to improve the diagnosis and treatment of severe magnesium deficiencies, which can lead to epileptic seizures and muscle cramps. read more
Research on the development of kidneys in prematurely born children
17 February 2022 Michiel Schreuder, together with Maastricht UMC+, is now starting a study into the kidneys of these children. For this, the researchers received a grant from the Kidney Foundation. read more
