On 11 January 2022, Laurens Verscheijden, theme Renal disorders, Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation", which he passed with flying colours.
Laurens’ supervisors were Frans Russel and Saskia de Wildt, theme Renal disorders and co-supervisor Jan Koenderink, theme Infectious diseases and global health. Based on the outstanding quality of the thesis and excellent defence the Examination Board awarded him the doctorate for exceptional performance with the distinction ‘cum laude’. Developmental processes in children can affect pharmacokinetics: “what the body does to the drug”, as well as pharmacodynamics: “what the drug does to the body”.
By a clever combination of lab experiments, clinical studies, and mathematical models, Laurens has developed mechanistic physiology-based pharmacokinetic models that could be used to predict brain drug concentrations and effects in children of different ages. These novel models can be considered a breakthrough in achieving more effective and safer dosing recommendations in children for drugs acting on the central nervous system.
Related news items
ZonMw grants to study optimal use of COVID-19 vaccines in patients with impaired immune systems3 February 2021
How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Our researchers received grants from ZonMw to make these studies possible.read more
RIMLS online award ceremony proudly presenting the winners13 January 2021
In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.read more
New insight into the effect of hydroxychloroquine undermines its use in corona11 June 2020
Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. Raphael Duivenvoorden was interviewed in the program Op1 at NPO1 to elaborate on the findings. It seems unlikely that chloroquine has beneficial effect in corona infections.read more
RIMLS PhD retreat registration is open23 January 2020
Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.read more
NWO Open Competition Domain Science - XS grant for Ronald van Rij and Jenny van der Wijst21 January 2020
NWO Domain Science has awarded Ronald van Rij, theme Infectious diseases and global health and Jennny van der Wijst, theme Renal disorders an XS grant. The XS category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea.read more