Welcome to Radboudumc Center for Infectious Diseases Mycobacterial infectious diseases

Contact Radboudumc Center for Infectious Diseases

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Our scientific research

The Radboudumc Center for Infectious Diseases research group aims to optimize treatment and outcome of mycobacterial diseases. We therefore combine basic science with pharmacology, microbiology, radiology, infectiology, and lung diseases. 

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Our scientific research

The Radboudumc Center for Infectious Diseases research group aims to optimize treatment and outcome of mycobacterial diseases. We therefore combine basic science with pharmacology, microbiology, radiology, infectiology, and lung diseases. 

Research overview

Member of the RCI mycobacterial infections perform in six Radboudumc research groups:

Research groups

Involved members

Expertise

Translational pharmacology of anti-microbial drugs, specifically anti-tuberculosis drugs 

Rob Aarnoutse 

Lindsey te Brake 

Elin Svensson (also Uppsala University, Sweden) 

  • Bio-analysis of drugs 
  • PK and PD data-analysis 
  • PBPK modeling  
  • Clinical trials 
  • Drug management 
  • Therapeutic Drug Monitoring 

Clinical tuberculosis and other mycobacterial infections 

Martin Boeree 

Cecile Magis-Escurra 

Wouter Hoefsloot 

Jodie Schildkraut 

Neeltje Carpaij 

  • Patient management 
  • Clinical trials and cohort studies 

 

Global Health and Infectious Diseases 

Reinout van Crevel (also Oxford University)

Arjan van Laarhoven 

Andrew Dinardo (also Baylor College of Medicine, USA) 

Vinod Kumar

  • Patient management  
  • Clinical trials and cohort studies 
  • Bio-analysis of inflammatory and defense markers  
  • Host-directed therapy 
  • Health policy and implementation research 

Clinical Microbiology 

Heiman Wertheim 

Jakko van Ingen 

  • Susceptibility testing, time-kill kinetics assays, hollow fiber model 
  • Clinical trials and cohort studies 
  • Clinical microbiology 

Pharmacology and Toxicology 

Frans Russel 

Jan Koenderink 

  • Molecular pharmacology 
  • Drug induced tolerance 
  • PBPK modelling 

Global Health Economics 

Rob Baltussen 

  • Health policy and implementation research 
  • Health economics 

Patients treated at Radboudumc for mycobacterial infections are able to participate in the Mycobacterial Cohort Study that gather clinical, microbiological and pharmacological data and is coupled to the Radboud biobank for later (immunological) measurements. 


Our education

Where can you learn more about mycobacterial infections at Radboudumc?

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Our education

Where can you learn more about mycobacterial infections at Radboudumc?

  • Latent tuberculosis pathophysiology (full day lecture, assignments and presentation by prof. Reinout van Crevel & dr. Arjan van Laarhoven in MED-MIN06, Minor Global Health & Infectious Diseases)
  • Tuberculosis treatment and drug resistance & risk factors for non-tuberculous mycobacterial infections (a lecture by dr. Wouter Hoefsloot & dr. Jakko van Ingen in MED-MIN29, ‘Control of Infectious Diseases)
  • Global HIV and tuberculosis co-infection, TB diagnostiscs and treatment latent TB treatment (1,5 day lectures, assignment and interactive clinical puzzle by Prof. Reinout van Crevel & dr. Jakko van Ingen & dr. Mischa Huson & dr. Arjan van Laarhoven  in MED-MINK16, ‘Minor in Global Health’)
  • Introduction to Tuberculosis (lecture by dr. Arjan van Laarhoven in MED-VK30-07, keuzemodule ‘Introduction to Global health')
  • Central nervous system infections including tuberculous meningitis (lecture by prof. dr. van Crevel in MINK-09, ‘The Fascinating Brain’)

Read more about education at RCI



Radboudumc center of clinical expertise for tuberculosis and non-tuberculous mycobacterial infectious diseases

Radboudumc is an acknowledged center of clinical expertise for tuberculosis and non-tuberculous mycobacterial infectious diseases (NTM). Healthcare professionals, such as pulmonologists, internists and other medical specialists, municipal health physicians in tuberculosis prevention, and general practitioners are able to obtain information and advice here. The center of expertise has a TBC-unit which is technically advanced in hygiene. Here, we treats patients from across the Netherlands and sometimes from well beyond its borders.
 

Read more in Dutch


International consortia and collaborators

RCI members also contribute to international consortia and collaborate with various international universities and research centers. 

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International consortia and collaborators

International consortia

RCI members also contribute to international consortia.

Clinical trials and pharmacokinetics of tuberculosis drugs

  • UNITE4TB consortium (prof. Martin Boeree, prof. Rob Aarnoutse, dr. Lindsey te Brake, prof Reinout van Crevel, dr. Cecil Magis, dr. Jakko van Ingen, dr. Elin Svensson): watch the video of UNITE4TB
  • PanACEA consortium (prof. Martin Boeree, prof. Rob Aarnoutse, dr. Lindsey te Brake, dr. Elin Svensson)

Tuberculosis diagnostics 

Prevention of diabetes-associated tuberculosis 

Tuberculous meningitis

  • Phase 3 RCT on high-dose rifampicin (HARVEST consortium on TB meningitis (prof. Rob Aarnoutse, prof. Reinout van Crevel, dr. Lindsey te Brake) 
  • Multi-omics analysis on pathogenesis and survival in adults (ULTIMATE; NIH/R01-AI145781-01) and children (INTERCEPT; R01AI165721) prof. Reinout van Crevel, dr. Arjan van Laarhoven, dr Vinod Kumar.

International collaborators

  • Universitas Padjadjaran (Bandung, Indonesia) 
  • University of Indonesia (Jakarta, Indonesia) 
  • KCMC/KCRI (Moshi, Tanzania) 
  • NIMR-MMRC (Mbeya, Tanzania) 
  • Makarere University (Kampala, Uganda)
  • TASK (Cape Town, South Africa)  
  • Nat. Instit. of Resp. Diseases and the Environment (AsunciĆ³n, Paraguay) 
  • University College London (London, UK) 
  • University of Zaragoza (Zaragoza, Spain) 
  • Forschungszentrum Borstel (Borstel, Germany) 
  • Centre for Tropical Medicine and Global Health, University of Oxford, UK
  • Otago University (Dunedin , New Zealand)

Research internships

We offer internships for motivated students in a variety of topics, such as: diagnostics, treatment including pharmacology, and mechanisms of disease including immunology. Please contact us and include your recent curriculum vitae.

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Clinical fellowships

We regularly host doctors in training for medical specialties in pulmonology or internal medicine/infectious diseases (“assistenten in opleiding tot specialist”, AIOS) and pharmacists in training. 

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