Research Departments Pharmacology and Toxicology

About us

Research of the department focuses on personalized pharmacotherapy and systems pharmacology/toxicology ranging from molecule to patient.

Contact

head of department

+31 (0)24 361 36 91
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Our researchers Pharmacology and Toxicology

A list of researchers connected to this department.

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Research groups Pharmacology and Toxicology

Discover some of our research that is related to pharmacology and toxicology.

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Themes


Facilities and services Pharmacology and Toxicology

This department wants to improve the efficacy and safety of drugs including drug overdoses and intoxications. We investigate the complete spectrum from the molecular to the clinical level.

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Facilities and services Pharmacology and Toxicology

Bioanalytical equipment for analysis of small molecule pharmaceuticals and toxicants in any biological matrix.

  • Liquid chromatography-tandem mass spectrometry - LC MS/MS
  • High performance liquid chromatography – HPLC
  • Custom-made method development for detection of small molecules in various biological matrices for research purposes.
  • See also our website RTC Mass Spectrometry website, as offer our expertise also to this RTC. 

Cell models

  • Overexpression of transport proteins in cells or vesicles.
  • Transport assays in cell models or with specific transport proteins.
  • Ample experience with culturing of various human placental trophoblast cell lines to study drug disposition and effects.
  • Ample experience with culturing and differentiating skeletal muscle myotubes.
  • Ample experience with culturing a patented in-house developed human conditionally immortalized proximal tubule cell line (ciPTEC)
  • Experience with culturing and differentiation of iPSC-derived cardiomyocytes.

Imaging

  • High-content and high-throughput microscopic imaging assays to asses multiple mitochondrial function parameters and cellular viability

Ex vivo models

  • small vessel myograph
  • ex vivo, dual-side human placenta perfusion to study placental drug transfer
  • ex vivo culture of placental villous tissue fragments to placental drug effects
  • Isolated contracting (human) atrial tissue model
  • Ussing Chamber for intestinal transport function (adult and pediatric)
  • Human cardiac auricle contractility analysis to study the effects of drugs on cardiac muscle function
  • Ussing chamber system

Human in vitro models

  • Conditionally immortalized proximal tubular epithelial cells (ciPTEC)
  • Kidney-on-chip
  • Vessel-on-chip model with HUVECs (in collaboration with Twente University)
  • HUVEC culture (in collaboration with Dept of Obstetrics); quantification of transporter expression and transporter function

Human in-vivo models

  • Perfused forearm model (with intrabrachial drug infusions and forearm blood flow measurements).

Data analysis and modelling

  • Physiologically-based pharmacokinetic/dynamic and toxicokinetic modelling
  • In silico prediction of plasma and tissue exposure of drugs and toxicants
  • Structure-based off-target modelling based on pharmacophore modelling of drug-protein interactions.
  • Metabolic flux modelling using human metabolic network reconstructions.
  • Molecular docking and virtual compound screening.

Education

At the Radboudumc we teach 6 Master courses that together form a firm basis for becoming a registered toxicologist. read more

Radboud Institute for Health Sciences

This department is affiliated with RIHS. The research at this institute aims to improve clinical practice and public health. institute pages

Radboud Institute for Molecular Life Sciences

This department is affiliated with RIMLS. Their main aim is to achieve a greater understanding of the molecular mechanisms of disease. institute pages

Getting there

Entrance: Study Center Medical Sciences
Route: 137

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Getting there

Visiting address

Department of Pharmacology and Toxicology
Geert Grooteplein 21
6525 EZ Nijmegen

Directions

Enter building at: Study Center Medical Sciences
Follow route 137 (Department of Pharmacology and Toxicology)