Department Pharmacology and Toxicology


Facilities and services Pharmacology and Toxicology

This department wants to improve the efficacy and safety of drugs including drug overdoses and intoxications. We investigate the complete spectrum from the molecular to the clinical level.

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Facilities and services Pharmacology and Toxicology

Equipment

  • Liquid chromatography-tandem mass spectrometry - LC MS/MS
  • High performance liquid chromatography – HPLC

Animal models

  • Murine model of bilateral renal ischemia-reperfusion injury 
  • Murine model of ischemic hindlimb exercise

Ex vivo models

  • isolated perfused rat kidney
  • mouse in situ kidney perfusion
  • small vessel myograph
  • placenta perfusion 

Data analysis and modelling

  • curve fitting and pharmacokinetic analysis
  • physiologically-based pharmacokinetic/toxicokinetic modelling
  • pharmacokinetic-dynamic modelling
Baculovirus-mediated overexpression of transporter proteins in a vesicle system or whole cells
Human forearm model of ischemia-reperfusion injury to study the effect of drugs on the vascular system. This can be combined with the use of  radioactively-labeled annexin A5 and scintigraphy.

Contact

Frans Russel PhD
+31 (0)24 361 36 91
Head of Department

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Education

At the Radboudumc we teach 6 Master courses that together form a firm basis for becoming a registered toxicologist.

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Themes


Radboud Institute for Health Sciences

This department is affliated with RIHS. The research at this institute aims to improve clinical practice and public health.

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Radboud Institute for Molecular Life Scineces

This department is aflliated with RIMLS. Their main aim is to achieve a greater understanding of the molecular mechanisms of disease.

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Getting there

Entrance: Radboudumc, East entrance (ingang Oost)
Route: 137/128

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Getting there

Visiting address

Department of Pharmacology and Toxicology
Reinier Postlaan 4
6525 EX Nijmegen

Directions

Enter building at: Radboudumc, East entrance (ingang Oost)
Follow route 137/128 (Department of Pharmacology and Toxicology)
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