Research group Kidney physiology

Achievements

• Provided insights into mechanisms of magnesium reabsorption in kidney

  We have identified of novel magnesium-wasting and salt-losing tubulopathies caused by mutations in CNNM2, PCBD1, KCNJ16, RRAGD and TRPM7. By linking genetic screening to functional studies, we have provided insights into the mechanisms of magnesium reabsorption in the kidney and improved diagnostics of patients with genetic kidney diseases.

• Magnesium prevents vascular calcification in vitro and in vivo

  We have shown that magnesium prevents vascular calcification in vitro and in vivo. In vascular smooth muscle cells (VSMC), magnesium effectively prevented high phosphate-induced mineralization, as well as in mouse models of CKD. Currently, clinical trials are in progress to determine the clinical relevance of magnesium supplements in CKD.

• Demonstrated that a percentage of people with diabetes suffer from hypomagnesemia

  We have demonstrated that 10-30% of all people with diabetes suffers from hypomagnesemia. Our work shows that magnesium affects insulin sensitivity and lipid metabolism. In clinical trials, we have evaluated benefits of magnesium for insulin sensitivity and immune function.

Publications

See the publication list of the research group leader on Web of Science.

• A selection of our publications

  • Magnesium Disorders - Touyz RM, de Baaij JHF, Hoenderop JGJ - 2024
  • Gitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA - Viering D, Schlingmann KP, Hureaux M, Nijenhuis T, Mallett A, Chan MMY, van Beek A, van Eerde AM, Coulibaly JM, Vallet M, Decramer S, Pelletier S, Klaus G, Kömhoff M, Beetz R, Patel C, Shenoy M, Steenbergen EJ, Anderson G, Bongers EMHF, Bergmann C, Panneman D, Rodenburg RJ, Kleta R, Houillier P, Konrad M, Vargas-Poussou R, Knoers NVAM, Bockenhauer D, de Baaij JHF; Genomics England Research Consortium - 2022
  • mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy - Schlingmann KP, Jouret F, Shen K, Nigam A, Arjona FJ, Dafinger C, Houillier P, Jones DP, Kleinerüschkamp F, Oh J, Godefroid N, Eltan M, Güran T, Burtey S, Parotte MC, König J, Braun A, Bos C, Rehmann H, Zwartkruis FJT, Renkema KY, Klingel K, Schulze-Bahr E, Schermer B, Bergmann C, Altmüller J, Thiele H, Beck BB, Dahan K, Sabatini D, Liebau MC, Vargas-Poussou R, Knoers NVAM, Konrad M, de Baaij JHF - 2021
  • Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review - Viering DHHM, Vermeltfoort L, Bindels RJM, Deinum J, de Baaij JHF - 2023
  • Long-Read Sequencing Identifies Novel Pathogenic Intronic Variants in Gitelman Syndrome - Viering DHHM, Hureaux M, Neveling K, Latta F, Kwint M, Blanchard A, Konrad M, Bindels RJM, Schlingmann KP, Vargas-Poussou R, de Baaij JHF. - 2023 
  • Liver and spleen predominantly mediate calciprotein particle clearance in a rat model of chronic kidney disease - Zeper LW, Bos C, Leermakers PA, Franssen GM, Raavé R, Hoenderop JGJ, de Baaij JHF - 2024
  • Magnesium prevents vascular calcification in Klotho deficiency - Ter Braake AD, Smit AE, Bos C, van Herwaarden AE, Alkema W, van Essen HW, Bravenboer N, Vervloet MG, Hoenderop JGJ, de Baaij JHF - 2020
  • Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes - Oost LJ, van der Heijden AAWA, Vermeulen EA, Bos C, Elders PJM, Slieker RC, Kurstjens S, van Berkel M, Hoenderop JGJ, Tack CJ, Beulens JWJ, de Baaij JHF - 2021
  • Magnesium increases insulin-dependent glucose uptake in adipocytes - Oost LJ, Kurstjens S, Ma C, Hoenderop JGJ, Tack CJ, de Baaij JHF - 2022
  • Magnesium reabsorption in the kidney - de Baaij JHF - 2023

Alumni

• Charlotte Hoogstraten
• Tengku Faris
• Anastasia Adella
• Willem Bosman
• Heidi Schigt
• Barnabas Ilenwabor
• Lara Zeper
• Lynette Oost
• Lotte Tholen
• Daan Viering
• Gijs Franken
• Chao Ma
• Lisanne Gommers
• Anique ter Braake
• Steef Kurstjens
• Andreas Kompatscher