We want to decipher the mechanisms of electrolyte disorders. We combine genetic analysis of patients with functional studies in cell and animal models to study the regulation of mineral handling by the kidney and mineral disturbances in cardiovascular and chronic kidney disease.
Research group leader
dr. Jeroen de Baaij
The development of next-generation diagnostics and innovative functional methods to measure magnesium transport are essential to diagnose and to understand magnesium-wasting tubulopathies. We envision that patient-specific models are the future of pathophysiological research. Personalized drug screening to identify therapeutics that fit the needs of individual patients will become the new standard for treatment of rare diseases
Cardiovascular complications are the main cause of death for patients with chronic kidney disease (CKD). Our research on magnesium in vascular calcification demonstrates that novel interventions can contribute to prevent cardiovascular disease in CKD. In our vision, better understanding of mechanisms of vascular calcification is essential to develop dietary and pharmacological approaches to reduce cardiovascular mortality and morbidity in CKD.
Our recent findings demonstrate that disturbed metabolic process result in urinary electrolyte wasting. We aim understand how metabolism and ion transport are related in the distal convoluted tubule of the kidney.