About this research group
This research group uses innovative methods including microdosing and microtracer technology, and physiology-based and population pharmacokinetic modeling, to contribute to a better understanding of the impact of age, disease and genetics on drug disposition in children.read more
Our research aims to elucidate variation in drug disposition and effect in special populations such as children and critically ill patients, taking into account age, disease and genetics. Human ex vivo, in vivo phenotyping, clinical trial as well as modeling and simulation approaches are used. Drug metabolism and membrane transport are focus of pharmacokinetic research, while pain/sedation and AKI are focus of pharmacodynamic research. We also aim to improve research infrastructure for pediatric clinical trials across Europe by participating at leadership level in several EU-funded initiatives. Clinical implementation of our and research from others is done trough the Dutch Pediatric Formulary, including model-informed dosing. The ultimate aim is to provide personalized effective and safe doses for special populations.