NL
DE
About this research group
This research group uses innovative methods including microdosing and microtracer technology, and physiology-based and population pharmacokinetic modeling, to contribute to a better understanding of the impact of age, disease and genetics on drug disposition in children. read moreAbout this research group
We have elucidated ontogeny of hepatic, liver and intestinal drug transporters across the pediatric age range, using ex vivo studies (immunohistochemistry, RT-PCR, RNAseq and proteomics). Using innovative methods including microdosing and microtracer technology, physiology-based and population pharmacokinetic modeling, we contributed to a better understanding of the impact of age, disease and genetics on drug disposition in children.
To optimize off-label drug in children, we developed and validated a dose calculator, verified clinically implemented dose changes and participated in off-label policy statements. We also lead the recent extension of the Dutch Pediatric Formulary to country-specific formularies across Europe. As part of the EU research infrastructure initiatives we host the Conect4children Strategic Feasibility Advisory Service and the Dutch Pediatric Trial Network PEDMED-NL.
