Researchers from Radboudumc have identified significant shortcomings in how pre-analytical sample processing is reported in clinical biomarker research, a factor crucial for study reliability and replicability. Examining 294 studies published between 2018 and 2023, the team found that essential details—such as fasting time (reported in only 31% of studies), freeze-thaw cycles (23%), internal sample transport (8.5%), and centrifugation settings (20–35%)—are frequently omitted. While demographic and storage data were better reported, these gaps persist regardless of journal prestige. The study underscores the urgent need for standardized reporting guidelines to enhance the quality and reproducibility of biomarker research. Based on this work, the Radboud Biobank recommends researchers include pre-analytical details in their publications on clinical biomarkers using biobanked biomaterials.
For more information:
Jansen JAW, van den Brand MA, de Vegt F, Swinkels DW. Reporting of Pre-Analytical Processes in Biobanked Biomaterials: A Missed Opportunity to Address the Replicability Crisis in Clinical Biomarker Research. Biopreserv Biobank. 2025 Sep 29. Online ahead of print. PMID: 41017129
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