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Within the field of diabetes, the group of Stienstra, van Diepen, de Galan, and Tack has focused on uncovering molecular pathways of disease that play a role in patients with diabetes, metabolic syndrome, or obesity:
- Uncovering the inflammatory mechanisms that underlie insulin resistance that occurs in obesity and metabolic diseases. Specifically, the role of the inflammasome, caspase-1 and cytokines of the interleukin-1 family have been investigated for their crucial part in obesity-induced inflammation. J Lipid Res 2013, Nat Com 2014, Clin Immunol 2015,
- Elucidating metabolism of immune cells, and their roles in metabolic diseases. Eur J Immunol 2016, Nat Microbiol 2016, Cell Metab 2017,
- Uncovering the mysteries of hypoglycemia in patients with diabetes is important, as too many individuals do not notice when a ‘hypo’ is occurring. J Clin Invest 2013, J Diabetes Sci Technol 2017, Diabetes 2017, Pharmacogenetic Genomics 2017, Diabetes 2017.
