Diabetes research at Radboudumc

Research Themes Metabolic disorders Diabetes research at Radboudumc

Within the field of diabetes, the group of Stienstra, van Diepen, de Galan, and Tack has focused on uncovering molecular pathways of disease that play a role in patients with diabetes, metabolic syndrome, or obesity:

Uncovering the inflammatory mechanisms that underlie insulin resistance that occurs in obesity and metabolic diseases. Specifically, the role of the inflammasome, caspase-1 and cytokines of the interleukin-1 family have been investigated for their crucial part in obesity-induced inflammation. J Lipid Res 2013, Nat Com 2014, Clin Immunol 2015,
Elucidating metabolism of immune cells, and their roles in metabolic diseases. Eur J Immunol 2016, Nat Microbiol 2016, Cell Metab 2017,
Uncovering the mysteries of hypoglycemia in patients with diabetes is important, as too many individuals do not notice when a ‘hypo’ is occurring. J Clin Invest 2013, J Diabetes Sci Technol 2017, Diabetes 2017, Pharmacogenetic Genomics 2017, Diabetes 2017.