Within the field of diabetes, the group of Stienstra, van Diepen, de Galan, and Tack has focused on uncovering molecular pathways of disease that play a role in patients with diabetes, metabolic syndrome, or obesity:
Uncovering the inflammatory mechanisms that underlie insulin resistance that occurs in obesity and metabolic diseases. Specifically, the role of the inflammasome, caspase-1 and cytokines of the interleukin-1 family have been investigated for their crucial part in obesity-induced inflammation. J Lipid Res 2013, Nat Com 2014, Clin Immunol 2015,