News - Radboudumc

Research Themes Reconstructive and regenerative medicine News

The following news items are related to the research Reconstructive and regenerative medicine.

4th ENABLE symposium a big success

27 May 2021

RIMLS PhD candidates co-organized this unique event with three other European research institutes (IRB Barcelona, CPR Copenhagen, SEMM Milan), which was facilitated by a competitive Horizon 2020 grant.

Miniaturized microfluidic platform for automated epigenetic profiling

6 May 2021

Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.

Broken teeth coronastress poses a danger to our teeth

6 May 2021

Teeth grinding and molars on top of each other: stress from corona causes an increase in dental damage. That's what they noticed at the department of dentistry at Radboudumc.

Millions of euros for study of laser treatment for glioblastoma

2 April 2021

A research group from Radboudumc and UMC Utrecht is to investigate laser treatment of a rare brain tumor, glioblastoma. 3.9 million euros has been made available for the research by Zorginstituut Nederland and ZonMw, under the auspices of the Subsidy Scheme for Promising Care.

Rare and complex urology: Clinical overview of ERN eUROGEN

25 March 2021

Wout Feitz and colleagues, theme Reconstructive & Regenerative Medicine, Department of Urology, Division of Pediatric Urology (Radboudumc Amalia Children’s Hospital) publish an article in European Urology which well indicates the impact of ERN developments.

Marie Curie Fellowship for Elena Macías Sánchez

24 March 2021

Elena Macías Sánchez has been awarded with a MSCA-IF to develop her project in the department of Biochemistry, RIMLS.

Horizon 2020 ERICA project approved by the EU

4 February 2021

In total there are 24 thematic ERNs. The Radboudumc participates in 14 networks. We are proud to say that two of these networks are coordinated from Radboudumc: ERN GENTURIS by Nicoline Hoogerbrugge and ERN eUROGEN by Wout Feitz.

RIMLS online award ceremony proudly presenting the winners

13 January 2021

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.

Targeting of radioactive platinum-bisphosphonate anticancer drugs to kill cancer cells in bone tumors

15 December 2020

Sander Leeuwenburgh and his team, theme Reconstructive and regenerative medicine, showed in a recently accepted paper (Materials Today Bio) that radioactive platinum-based anticancer drugs can be targeted towards bone tumors to killl tumor cells inside these tumors.

Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation

28 October 2020

A multidisciplinary team of RIMLS and Radboud University researchers published in Advanced Science that Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation.

Making bones is less difficult than was previously thought Ten-year controversy settled with publication in Nature Communications

15 October 2020

The way in which bone formation occurs need to be redefined. This was revealed in a publication in Nature Communications by Nico Sommerdijk, theme Reconstructive and Regenerative Medicine, and his colleagues.

Marie Skłodowska-Curie ITN SkinTERM coordinated by Willeke Daamen and Toin van Kuppevelt

6 October 2020

The European Union has granted more than 3 million euro to the SkinTERM project “Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration”. SkinTERM is coordinated by Willeke Daamen en Toin van Kuppevelt.

Frank Walboomers 25-years work anniversary at Radboudumc

17 September 2020

Frank Walboomers, associate professor at the research group Regenerative Biomaterials at the Dept. of Dentistry (theme Reconstructive & Regenerative Medicine), celebrated his 25th work anniversary at Radboudumc.

Frank Wagener and Hans Von den Hoff obtained a grant to study cleft palate repair in a rat model

18 August 2020

Umbilical cord stem cells for cleft palate surgery.

ATRO Medical, Radboudumc and Samaplast develop new meniscus prosthesis Consortium receives EUROSTARS grant for innovative project

16 July 2020

An international consortium led by ATRO Medical, a spin-off of Radboudumc and DSM, will receive € 800,000 European funding for an innovation aimed at patients with knee osteoarthritis. These patients often suffer from cartilage wear due to a meniscus that no longer works properly.

Radboud Science Award for RIHS researchers

24 June 2020

Maroeska Rovers, Machteld van Egmond and Niels van Heerbeek have been awarded the Radboud Science Award 2020. The awardees receive the prize for their research of the necessity of correcting the nasal septum.

Hemolysis may exacerbate lung complications in COVID-19 patients

23 June 2020

Frank Wagener, theme RRM, postulates in a viewpoint publication in Antioxidants that the Heme-Heme Oxygenase system could be targeted to prevent severe complications following COVID-19 infections.

Grant for early detection of ovarian cancer

5 June 2020

The Department of Biochemistry (Toin van Kuppevelt/Willeke Daamen), together with the Department of Gynecology, has been awarded a grant of 144 kEuro for the development of an assay for the early detection of ovarian cancer.

3 million euro for Marie Curie ITN SkinTERM

5 June 2020

The European Union has provisionally awarded a grant of more than 3 million euro to the SkinTERM project “Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration”. SkinTERM is coordinated with Willeke Daamen as coordinator and Toin van Kuppevelt as vice coordinator.

Intra-articular corticosteroid injections increase the risk of requiring knee arthroplasty

14 May 2020

In The Bone & Joint Journal, RIHS researcher Stan Wijn et al. showed that corticosteroid injections in the knee joint are associated with an increased risk of knee arthroplasty in patients with, or at risk of developing, symptomatic osteoarthritis of the knee.

A tunable and injectable local drug delivery system for personalized periodontal application

11 May 2020

In Journal of Controlled Release, Fang Yang and colleagues, have designed and formulated a local delivery system by loading the PLGA-drug microspheres into PIC hydrogel. This system exhibited appropriate injectability, long-term structural stability, and no obvious in vivo inflammatory response.

Bart van den Bemt appointed as professor of Personalized Pharmaceutical Care

22 April 2020

Bart van den Bemt will pay particular attention to shared decision-making, improved treatment adherence, effective pharmacotherapy and sustainable drug use.

Clinic for tooth wear interaction education, research and patient care

9 March 2020

No extravagance entrance, no screaming advertisements, … but nevertheless a couple of proud colleagues. Hanneke Huijs-Visser and Bas Loomans are the initiators of this clinic.

FET-OPEN grant for Toin van Kuppevelt and Willeke Daamen

6 March 2020

A grant of 592 kEuro has been awarded to Toin van Kuppevelt and Willeke Daamen, theme Reconstructive and regenerative medicine, for a Horizon 2020 FET-OPEN project entitled “Heparin and heparan sulphate: from sequence determination to therapeutic strategies for Parkinson’s disease”.

Plugging the gap ZonMw/Health Holland grant

3 March 2020

RIMLS en RIHS researchers Willeke Daamen, Frank Vandenbussche, Joris van Drongelen, Toin van Kuppevelt and Janneke Grutters have been granted 1.3 million euro for the development and evaluation of a new technology to prevent premature rupture of fetal membranes (iPPROM).

Three Vici grants for Radboudumc researchers

20 February 2020

Christian Beckmann, Sander Leeuwenburgh and Annette Schenck each receive a 1.5 million euro Vici research grant from NWO.

RIMLS PhD retreat registration is open

23 January 2020

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

The PRIDE Study Evaluation of online methods of data collection

16 January 2020

In Paediatric and Perinatal Epidemiology RIHS researchers Marleen van Gelder and Nel Roeleveld described the recruitment methods and online data collection within the PRIDE Study, the largest Dutch birth cohort study.

RIMLS awards call for nominations

26 November 2019

RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.

A personal touch of Sander Leeuwenburgh

21 November 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Sander Leeuwenburgh.

Awardees RIHS Junior Researcher round 2020

23 October 2019

Recently, RIHS held an internal call for Radboudumc junior researcher (PhD) positions. This year 6 positions have been awarded.

Merel Ritskes-Hoitinga has been appointed honorary Skou professor at Aarhus University

17 October 2019

Merel Ritskes-Hoitinga has been appointed honorary Skou Professor at the Dept. of Clinical Medicine, at Aarhus University. The aim is to introduce new perspectives to teaching, strengthen relations with leading research units abroad and establish joint research projects and funding applications.

A personal touch of Frank Wagener

10 October 2019

RIMLS 25 years jubilee festival The Future is Yesterday

3 October 2019

Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...

Charity event for children with a diaphragmatic defect

26 September 2019

For the third year in a row, Rotary Ridderkerk - de Waal organised a golf tournament, dinner and auction to raise research funds for children with congenital diaphragmatic hernia. At the end of the day, a cheque worth € 51,000 was handed over to Sanne Botden and Willeke Daamen.

RIMLS PhD grants awarded to eight RIMLS (j)PI's

12 September 2019

Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects.

Phantomless calibration of CT scans for fracture risk assessment in cancer patients with femoral bone metastases

5 September 2019

In Plos One, Florieke Eggermont, Esther Tanck and colleagues developed a calibration method, which makes clinical implementation of CT-based finite element models as tool for fracture risk assessment easier.

A personal touch of John Heesakkers

29 August 2019

Publication in PNAS on dissecting EEC syndrome using single-cell RNA-seq

22 August 2019

PhD candidates Eduardo Soares and Quan Xu in Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstruction and regenerative medicine, have published a paper in PNAS on the disease mechanism of EEC syndrome using single-cell RNA-seq technology and patient-derived iPSCs.

NWO grant for a tissue-generating patch to close diaphragmatic defects

21 August 2019

Willeke Daamen and Toin van Kuppevelt, theme Reconstructive and regenerative medicine, were recently awarded a 690 k€ grant by NWO, domain Applied & Engineering Sciences, for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.

NWO grant to develop new biomaterials for improved regeneration of bone defects

20 August 2019

Sander Leeuwenburgh, theme Reconstructive and regenerative medicine, and Roland Brock, theme Nanomedicine, were recently awarded with a grant of 581 k€ by NWO, domain Applied & Engineering Sciences, to develop new biomaterials for improved regeneration of bone defects.

Bas Loomans received Mid-Career Award

18 July 2019

Bas Loomans received in Vancouver the STEPHEN BAYNE MID-CAREER AWARD of the International Association for Dental Research (IADR)

Surgery to straighten a deviated septum improves quality of life

20 June 2019

Patients with a deviated septum breathe more easily after a septoplasty and their quality of life improves. Specialists have long debated its benefits. Machteld van Egmond, Maroeska Rovers, and Niels van Heerbeek have ended the controversy with a publication in The Lancet.

H2020 Grant for Frank Walboomers and Ronald Bartels

23 May 2019

Frank Walboomers and Ronald Bartels, theme Reconstructive and regenerative medicine, have received a € 500,000 grant for research into graphene biomaterials from the Europan Union Horizon 2020 FET Open programme.

Association of gestational weight gain with adverse maternal and infant outcomes

13 May 2019

An individual participant meta-analysis published in JAMA showed that pregnancy BMI is related stronger to maternal and infant complications than to gestational weight gain. The PRIDE Study, with coauthors Marleen van Gelder and Nel Roeleveld, was one of the participating cohorts.

Sónia Schickert represents the Netherlands at the XVI Conference of the European Ceramic Society

9 May 2019

Sónia Schickert, theme Reconstructive and regenerative medicine, will represent the Netherlands at the XVI conference of the European Ceramic Society in Torino, Italy.

Toughened calcium phosphate bone cements using PVA Fibers

2 May 2019

Nathan Kucko and Sónia de Lacerda Schickert, and colleagues, published in ACS Biomaterials Science and Engineering that the incorporation of poly fibers in calcium phosphate bone cements substantially improves their strength and toughness while maintaining their ostecompatibility.

Step-up approach vs open necrosectomy for necrotizing pancreatitis

18 April 2019

Another publication of the successful Dutch collaborative group on pancreatitis research with substantial contribution from Radboudumc researchers, Harry van Goor and Kees van Laarhoven.

Call for RIMLS Junior Researcher 2020

24 March 2019

In 2020 funding will be made available for 8 RIMLS Junior Researcher projects. The call for these PhD grants is now open.

Biomaterials-aided mandibular reconstruction using in vivo bioreactors

22 March 2019

In a collaborative effort, John Jansen en Jeroen van den Beucken, theme Reconstructive and regenerative medicine, have demonstrated in PNAS the feasibility of an in vivo bioreactor-based strategy to generate vascularized bony tissue and its use for mandibular reconstruction.

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