Making bones is less difficult than was previously thought Ten-year controversy settled with publication in Nature Communications15 October 2020
The way in which bone formation occurs need to be redefined. This was revealed in a publication in Nature Communications by Nico Sommerdijk, theme Reconstructive and Regenerative Medicine, and his colleagues.
Marie Skłodowska-Curie ITN SkinTERM coordinated by Willeke Daamen and Toin van Kuppevelt6 October 2020
The European Union has granted more than 3 million euro to the SkinTERM project “Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration”. SkinTERM is coordinated by Willeke Daamen en Toin van Kuppevelt.
ATRO Medical, Radboudumc and Samaplast develop new meniscus prosthesis Consortium receives EUROSTARS grant for innovative project16 July 2020
An international consortium led by ATRO Medical, a spin-off of Radboudumc and DSM, will receive € 800,000 European funding for an innovation aimed at patients with knee osteoarthritis. These patients often suffer from cartilage wear due to a meniscus that no longer works properly.
3 million euro for Marie Curie ITN SkinTERM5 June 2020
The European Union has provisionally awarded a grant of more than 3 million euro to the SkinTERM project “Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration”. SkinTERM is coordinated with Willeke Daamen as coordinator and Toin van Kuppevelt as vice coordinator.
Intra-articular corticosteroid injections increase the risk of requiring knee arthroplasty14 May 2020
In The Bone & Joint Journal, RIHS researcher Stan Wijn et al. showed that corticosteroid injections in the knee joint are associated with an increased risk of knee arthroplasty in patients with, or at risk of developing, symptomatic osteoarthritis of the knee.
A tunable and injectable local drug delivery system for personalized periodontal application11 May 2020
In Journal of Controlled Release, Fang Yang and colleagues, have designed and formulated a local delivery system by loading the PLGA-drug microspheres into PIC hydrogel. This system exhibited appropriate injectability, long-term structural stability, and no obvious in vivo inflammatory response.
FET-OPEN grant for Toin van Kuppevelt and Willeke Daamen6 March 2020
A grant of 592 kEuro has been awarded to Toin van Kuppevelt and Willeke Daamen, theme Reconstructive and regenerative medicine, for a Horizon 2020 FET-OPEN project entitled “Heparin and heparan sulphate: from sequence determination to therapeutic strategies for Parkinson’s disease”.
Plugging the gap ZonMw/Health Holland grant3 March 2020
RIMLS en RIHS researchers Willeke Daamen, Frank Vandenbussche, Joris van Drongelen, Toin van Kuppevelt and Janneke Grutters have been granted 1.3 million euro for the development and evaluation of a new technology to prevent premature rupture of fetal membranes (iPPROM).
RIMLS PhD retreat registration is open23 January 2020
Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.
A personal touch of Sander Leeuwenburgh21 November 2019
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t. This week: Sander Leeuwenburgh.
Merel Ritskes-Hoitinga has been appointed honorary Skou professor at Aarhus University17 October 2019
Merel Ritskes-Hoitinga has been appointed honorary Skou Professor at the Dept. of Clinical Medicine, at Aarhus University. The aim is to introduce new perspectives to teaching, strengthen relations with leading research units abroad and establish joint research projects and funding applications.
RIMLS 25 years jubilee festival The Future is Yesterday3 October 2019
Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
Charity event for children with a diaphragmatic defect26 September 2019
For the third year in a row, Rotary Ridderkerk - de Waal organised a golf tournament, dinner and auction to raise research funds for children with congenital diaphragmatic hernia. At the end of the day, a cheque worth € 51,000 was handed over to Sanne Botden and Willeke Daamen.
Phantomless calibration of CT scans for fracture risk assessment in cancer patients with femoral bone metastases5 September 2019
In Plos One, Florieke Eggermont, Esther Tanck and colleagues developed a calibration method, which makes clinical implementation of CT-based finite element models as tool for fracture risk assessment easier.
Publication in PNAS on dissecting EEC syndrome using single-cell RNA-seq22 August 2019
PhD candidates Eduardo Soares and Quan Xu in Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstruction and regenerative medicine, have published a paper in PNAS on the disease mechanism of EEC syndrome using single-cell RNA-seq technology and patient-derived iPSCs.
NWO grant for a tissue-generating patch to close diaphragmatic defects21 August 2019
Willeke Daamen and Toin van Kuppevelt, theme Reconstructive and regenerative medicine, were recently awarded a 690 k€ grant by NWO, domain Applied & Engineering Sciences, for the development of advanced patches for closure of diaphragmatic defects in children with congenital diaphragmatic hernia.
NWO grant to develop new biomaterials for improved regeneration of bone defects20 August 2019
Sander Leeuwenburgh, theme Reconstructive and regenerative medicine, and Roland Brock, theme Nanomedicine, were recently awarded with a grant of 581 k€ by NWO, domain Applied & Engineering Sciences, to develop new biomaterials for improved regeneration of bone defects.
Surgery to straighten a deviated septum improves quality of life20 June 2019
Patients with a deviated septum breathe more easily after a septoplasty and their quality of life improves. Specialists have long debated its benefits. Machteld van Egmond, Maroeska Rovers, and Niels van Heerbeek have ended the controversy with a publication in The Lancet.
Association of gestational weight gain with adverse maternal and infant outcomes13 May 2019
An individual participant meta-analysis published in JAMA showed that pregnancy BMI is related stronger to maternal and infant complications than to gestational weight gain. The PRIDE Study, with coauthors Marleen van Gelder and Nel Roeleveld, was one of the participating cohorts.
Toughened calcium phosphate bone cements using PVA Fibers2 May 2019
Nathan Kucko and Sónia de Lacerda Schickert, and colleagues, published in ACS Biomaterials Science and Engineering that the incorporation of poly fibers in calcium phosphate bone cements substantially improves their strength and toughness while maintaining their ostecompatibility.
Biomaterials-aided mandibular reconstruction using in vivo bioreactors22 March 2019
In a collaborative effort, John Jansen en Jeroen van den Beucken, theme Reconstructive and regenerative medicine, have demonstrated in PNAS the feasibility of an in vivo bioreactor-based strategy to generate vascularized bony tissue and its use for mandibular reconstruction.
€180k for Orthopaedic Research Laboratory31 January 2019
Researchers of the Orthopaedic Research Laboratory of the Radboudumc, together with the LUMC, received a grant of €180k from the Innovatiefonds Zorgverzekeraars for clinical implementation of patient-specific computer models for fracture risk prediction in patients with bone metastases.
The master regulatory role of the transcription factor p63 in skin disease24 January 2019
PhD candidate Jieqiong Qu from Jo Huiqing Zhou’s group in Molecular Developmental Biology, theme Reconstructive and regenerative medicine, has published a paper in Cell Reports on the master regulatory role of the transcription factor p63 in skin disease.