Saskia de Wildt and colleagues, theme Renal disorders, obtained an EU Horizon 2020 grant of € 123.000 for a new research infrastructure that will facilitate the future development of better paediatric medicines.Children and young people represent 20 % of the European population. When we refer to this group of people as patients, it’s essential to consider that they are different from the adult patients. Their metabolism is different, because they are in continuous development and also they can suffer diseases that sometimes might be limited to the paediatric setting.Taking into consideration these specificities, the need of treatments addressed only for children is a public priority. Nowadays around 50% of the medicines that are prescribed to paediatric patients have not been tested specially for them. For this reason, it is essential to promote and increase paediatric research.
The translation between bench to the bedside requires the involvement of different expert research groups in drug early discovery, biomarkers, formulation, pharmacology, etc. that already collaborate in Europe within the already existing research infrastructures. But the problem is that they do not are specifically dedicated to research in children.The time needed for the development of new medicines is also an important concern. It is long, from the basic research (before the study of a potential treatment with humans) to the clinical research (when we study this potential treatment with patients). It can also take among 7-10 years from the screening of new molecules to the market of a new drug and the average of success rate is really low (1 over 10.000 molecules studied). For this reason, it's essential to join efforts and work in a collaborative way between the European experts groups that at this moment are working to develop paediatric medicines.
ID-EPTRI is a project funded by the European Commission that has as main objective to design the framework for the European Paediatric Translational Research Infrastructure (EPTRI). A research infrastructure is a set of facilities, resources and related services at disposal of the scientific community to conduct top-level research. EPTRI will be a new research infrastructure that will integrate the paediatric expertise of five different areas of pre-clinical research: early discovery and preclinical studies, biomarkers, pharmacology, formulation and underpinning paediatric studies. The main objective of ID-EPTRI is to facilitate the paediatric pre-clinical research while reducing the time of its translation to the clinical phase.
The project involves 26 partners from EU and non-EU countries including already existing research infrastructures, top-level universities, scientific and clinical centers of excellence in Europe. It is coordinated by Consorzio per Valutazioni Biologiche e Farmacologiche (CVBF), a not-for-profit organization, founded in 2000 with the mission to perform research and provide scientific, economic and regulatory consultancy for innovation in the health sector at European level.
Saskia de Wildt, project leader, is member of the theme Renal disorders.
Related news items
Studying the function of liver cancer genes in mini-organs24 May 2019
Michiel Vermeulen, theme Cancer developement and immune defense, and colleagues, have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer. Their results were published in the scientific journal Cell Stem Cell.read more
Three VIDI grants for RIMLS researchers24 May 2019
Three researchers from RIMLS are each to receive up to 800,000 euros to develop an innovative research theme and to build up their own research group. NWO (The Netherlands Organisation for Scientific Research) is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.read more
H2020 Grant for Frank Walboomers and Ronald Bartels23 May 2019
Frank Walboomers and Ronald Bartels, theme Reconstructive and regenerative medicine, have received a € 500,000 grant for research into graphene biomaterials from the Europan Union Horizon 2020 FET Open programme.read more
Innovation Grant Dutch Kidney Foundation for Jeroen de Baaij23 May 2019
Jeroen de Baaij, theme Renal disorders, was awarded with an Innovation Grant of the Dutch Kidney Foundation. Jeroen's research proposal was selected from a competitive field of innovative approaches to treat kidney disease.read more
Graduate school news Adjusted PhD guidelines23 May 2019
It should be emphasized that the quality, and not the number of chapters, determines the assessment by the manuscript committee. To avoid the wrong emphasis on quantity, it is not recommended to have more than three publishable chapters in the thesis.read more