Research theme Renal disorders

Renal disorders About theme

The mission of the renal disorders theme is to deliver excellent, efficient and innovative clinical care to our patients at the Radboudumc and beyond, and to be leading in the field of kidney disease research. The primary aim of the renal disorders theme is to understand the molecular mechanisms, physiology and pathogenesis of glomerular diseases and tubular transport disorders, including acquired and inherited forms of kidney diseases. To achieve this aim, we will increase knowledge of the molecular and immunological basis of glomerular and tubular disorders; develop biomarkers for optimal prediction of disease prognosis; and apply strategies for preventing and improving renal replacement therapy. The research projects are carried out at genetic, molecular, cellular and integrative levels, as well as on human subjects.

Objectives

• We will increase knowledge of the molecular and immunological basis of glomerular and tubular disorders and of graft performance.
• We will combine genetic and functional cutting-edge methodology to diagnose and identify novel renal diseases.
• We will identify novel therapeutic targets for renal disorders and kidney transplant survival.
• We aim to develop biomarkers for optimal diagnosis, prevention and prognosis of renal diseases, kidney injury and transplant survival.
• We aim to optimize treatment strategies for patients with renal diseases, focusing on patient-tailored treatment.
• We will apply strategies for preventing and improving renal replacement therapy.