1 June 2018

Three RIMLS researchers received each 800,000 euros to develop an innovative research project and to build up their own research group. NWO (The Netherlands Organisation for Scientific Research) is awarding the Vidi grant as part of the Innovational Research Incentives Scheme.

Vidi is aimed at excellent researchers who have been producing successful research for a number of years since obtaining their PhD. These academics are among the best 10 to 20 percent in their field. A Vidi will allow them to conduct research for a period of five years. In this way, NWO stimulates curiosity-driven and innovative research.

Information about the RIMLS scientists and their research is given below.

How to read the genome

Simon van Heeringen (FNWI), theme Cancer development and immune defense.
A fertilized egg cell develops into a complete organism with many different cell types. How is this encoded in the genome? Biologists will compare the development of different animals. Using ‘big data’ they will train computer algorithms to understand cellular decisions. This knowledge will be essential for regenerative medicine.

Why do healthy people die of the flu?

Frank van de Veerdonk, theme Infectious diseases and global health
A pandemic is inevitable and will cost millions of lives including many healthy adults. Deadly complications of the flu are fungal infection or a life-threatening inflammatory response. This research will identify why these complications happen and can lead to treatment that can save lives during a severe flu season.

A microchip-based toolbox to treat osteoporosis

Alireza Dolatshahi-Pirouz, theme Reconstructive and regenerative medicine
Due to the aging population new innovations are needed for dealing with osteoporosis the most common disability among today’s elderly. Regenerative medicine can address this challenge through hydrogel- based stem cell therapies. The goal is to develop a toolbox for testing thousands of such therapies in a single experiment.
 

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Imprinted genes during early embryonic development

18 February 2019

René Dirks, with other members from the lab of Hendrik Marks, theme Cancer development and immune defense, show in a paper in Epigenetics & Chromatin that genomic imprinting (genes expressed from the paternal or maternal allele only) is often lost in cultured embryonic stem cells.

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The first Radboud Nanomedicine community networking event

14 February 2019

On 7 February 2019 the first Radboud Nanomedicine community networking event took place. The goal of the event was to bring together all those working in the field of nanomedicine at the Radboud University and Radboudumc, irrespective of the theme in which the research is performed.

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Research Integrity Round: The ConScience App 15 February 2019

14 February 2019

To introduce the new Netherlands Code of Conduct for Research Integrity we invited ‘Het Acteursgenootschap’ to perform ‘The ConScience App’, a theatre piece designed to move the debate on scientific knowledge. All Radboudumc researchers are invited to attend this event.

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Gene involved in colorectal cancer also causes breast cancer

14 February 2019

Judith Grolleman, Nicoline Hoogerbrugge and Richarda de Voer, theme Tumors of the digestive tract, published in Cancer Cell that mutations in the NTHL1 gene, previously associated with colorectal cancer, also cause breast cancer and other types of cancer.

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Endometrial natural killer cells remember previous pregnancy

11 February 2019

Dorien Feyaerts, theme Inflammatory diseases, showed that pregnancy induces a memory phenotype on endometrial natural killer cells. However, previous CMV infection is a prerequisite for this memory induction. They published their findings in Cellular and Molecular Immunology.

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A personal touch of Iris Nagtegaal

10 February 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Iris Nagtegaal.

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