Worldwide more than 500 million people suffer of tropical infectious diseases such as malaria, dengue, and zika, which are transmitted by mosquitoes. Members of the Nanomedicine theme (department of Synthetic Organic Chemistry) collaborate with Radboudumc and the spin-off companies Protinhi Therapeutics and TropIQ Health Sciences in the Tropinhi consortium. The project is supported by a grant of the European Regional Development Fund, the Netherlands and the Province of Gelderland.
The ‘TropInhi’ project involves all aspects of medicinal chemistry, mainly organic synthesis at the chemistry department, but also chemical design, molecular modeling, biological assays, and the assessment of structure-activity relationships in collaboration with the project partners, the Radboudumc, and the companies TropIQ and ProtInhi. Chemical starting points include heterocyclic compounds killing malaria parasites, and peptide-like protease inhibitors targeting the dengue and zika viruses.