Gut microbiota alleviates effects of stress on cognition3 June 2021
Researchers from the Radboudumc and Donders Institute have shown that the gut microbiota is involved in the protecting effects of probiotics on cognitive performance in acute stress circumstances. Their results are now published in Translational Psychiatry.
Miniaturized microfluidic platform for automated epigenetic profiling6 May 2021
Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.
Higher education does not influence how the brain ages28 April 2021
Contrary to popular belief, a new study from the Lifebrain consortium at the University of Oslo finds that higher education does not slow brain aging. Radboudumc and Donders Institute researcher Rogier Kievit is also part of this study.
Brain region controls pathological aggression but leaves context-appropriate aggresion intact21 April 2021
In recent work published in Current Biology, researchers from Radboudumc and Donders Institute, as well as other international collaborators, showed that in mice, anterior cingulate cortex dials down excessive aggression, but leaves context-appropriate aggression intact.
Lack of evidence for genetic defects in previously implicated gene in patients with male infertility20 April 2021
In a letter to Cell, researchers from the department of Human Genetics at Radboudumc have raised concerns about the claimed role of PIWIL1 D-box region mutations in human male infertility in an earlier publication in the same journal.
ADHD-related alterations in brain organization based on different brain profiles14 April 2021
Structural differences between the brains of people with and without ADHD are extensively reported. In accordance with earlier (ENIGMA) studies, and using a large cohort, a newly published study builds upon these by showing differences in brain organization that is based on different brain profiles.
Seven million cases of Parkinson's disease The fastest growing brain disease in the world13 April 2021
Over seven million people worldwide have Parkinson's disease, and it is the fastest growing brain disease in the world. Different forms of personalized treatment plans are needed. This is what Radboudumc neurologist Bas Bloem writes in a review article published in The Lancet.
SATB1 - Three classes of mutations and their unique rare diseases18 February 2021
Recent advances in DNA sequencing technologies have made it possible to uncover the causes of multiple rare diseases. A new collaborative study describes how three classes of mutation within the same gene result in different neurodevelopmental disorders.
Cell-type specific changes induced by culturing on microfluidic chips.10 February 2021
A collaborative TURBO (Twente University RadBoudumc Opportunities) project, recently published in Scientific Reports, developed an organ-on-a-chip device which can be used for modelling the neurovascular unit (NVU).
Four new professors explain the need for cooperation in developmental neuroscience27 January 2021
In the past, developmental neuroscience was not a field in which people from different disciplines cooperated very much. However, in recent years, the approach has been gradually changing. Four newly appointed professors at Radboudumc/ the Donders Institute understand the importance of teaming up.
Tjitske Kleefstra appointed endowed professor of Clinical genetics and psychopathology of rare syndromes17 September 2020
Tjitske Kleefstra has been appointed endowed professor of Clinical genetics and psychopathology of rare syndromes at the department of Neurodevelopmental disorders, with effect from 1 September.
Annette Schenck appointed professor of Translational Genomics of Neurodevelopmental Disorders17 September 2020
Annette Schenck has been appointed professor of Translational Genomics of Neurodevelopmental Disorders. with effect from 1 August. The chair will bring together fundamental and translational research in the field of brain developmental disorders.
Nanda Rommelse appointed endowed professor of Neurodevelopmental disorders8 September 2020
Nanda Rommelse has been appointed professor of Neurodevelopmental disorders with effect from 1 September. The chair will function as a bridge between the Psychiatry Department of the Radboudumc with Karakter Child and Adolescent Psychiatry.
6 million euros to uncover link between metabolic and brain disorders21 January 2020
An important European-funded initiative, coordinated by Radboudumc researchers Barbara Franke, Jan Buitelaar, and Janita Bralten, has been launched to explore how common molecular mechanisms may link metabolic disorders with brain disorders.
Rubicon Grant for Marieke Klein14 January 2020
DCMN researcher Marieke Klein, theme Neurodevelopmental disorders, received a Rubicon Grant from the Dutch Organisation for Scientific Research (NWO). The Rubicon program gives young, highly promising researchers the opportunity to gain international research experience.
Two DCMN researchers in top 1 percent by citations28 November 2019
Jan Buitelaar and Christian Beckmann made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
1.5 million for research into young people with mild intellectual disabilities13 November 2019
Researchers from the Radboud University and Radboudumc will partner with social organisations to map how often young people with mild intellectual disabilities have psychological problems and how they can be treated. The project was recently awarded a subsidy of 1.5 million euro by ZonMw.
Self-management rehabilitation program improves participation in patients with neuromuscular disease4 November 2019
Yvonne Veenhuizen, Alexander Geurts theme Neurorehabilitation, Baziel van Engelen, theme Disorders of movement, and colleagues, showed that Energetic improves participation in patients with neuromuscular disease. They have published their results in Neurology.
Front cover Human Mutation21 August 2019
The MetaDome web server build to interpret genetic variants based on genetic tolerance and homologous protein domains is featured on the Cover of Human Mutation. MetaDome was developed by Laurens van de Wiel, Coos Baakman, Daan Gilissen, Joris Veltman, Gert Vriend and Christian Gilissen,
How a gene called G9a regulates the energy supply for stress18 March 2019
In order to survive, all organisms must be able to detect (threatening) changes in their environment and respond to them adequately and quickly. However, such stress responses (e.g., escape from a predator or immune response to an infection) are very energy-consuming.
3 DCMN researchers among most cited scientists10 December 2018
Christian Beckmann, Jan Buitelaar and Barbara Franke made it to this year’s list of highly cited researchers. Scientists in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
Researchers have found the first risk genes for ADHD New insight into the biology behind ADHD.28 November 2018
A major international collaboration headed by researchers from the Danish iPSYCH project, the Broad Institute of Harvard and MIT, and the Psychiatric Genomics Consortium has - for the first time - identified genetic variants which increase the risk of ADHD.
Very few similarities between the brains of schizophrenia patients Research at group level says little about the individual patient16 October 2018
Patients with a diagnosis of schizophrenia are a heterogenous group with large differences between individuals. Researchers at the Radboudumc showed that only a negligible number of identical features in the brain occur in more than two percent of patients.
Researchers and industry join forces to unravel and treat autism Public-private project AIMS-2 receives 110 million euros from IMI12 July 2018
In a large public-private project, supported by 110 million euros by the IMI, a large consortium of researchers will search for biomarkers with which people with autism can be divided into clear subgroups.
A low cholesterol level is not a good thing21 June 2018
Research shows that low cholesterol can also be harmful. Researchers from Radboudumc and their Australian and American colleagues discovered a new metabolic defect, producing very low cholesterol levels. This causes brain anomalies, developmental delay, epilepsy and typical facial deformities.