Research Themes Reconstructive and regenerative medicine

Reconstructive and regenerative medicine About theme

The theme focuses on the development and clinical translation of innovative diagnosis and reconstructive therapies, including regenerative medicine and nanomedicine, towards personalized care and cure of patients needing reconstructions of lost or damaged tissues.

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Reconstructive and regenerative medicine About theme

The theme focuses on the development and clinical translation of innovative diagnosis and reconstructive therapies, including regenerative medicine and nanomedicine, towards personalized care and cure of patients needing reconstructions of lost or damaged tissues. This is achieved by transdisciplinary research between research groups in the fields of cell biology, biomaterials and bioengineering, in close collaboration with clinical experts.

Reconstructive and regenerative medicine (RRM) is a rapidly emerging field in translational medicine. It aims at improving quality of life and, if possible, extending lifespan through healthy aging, by developing reconstructive and curative therapies for diseases caused by structural anomalies, tissue damage, and ensuing organ dysfunction. Regenerative medicine takes full advantage of contemporary developments in stem cell and molecular biology, epigenetics, genomics and proteomics, biomaterials, and bioengineering. They emerge from advances in molecular diagnostics, image-guided therapies for minimally invasive treatments, nanomedicine, novel devices, advanced therapy medicinal products and drugs. Furthermore, both reconstructive and regenerative medicine benefit from new surgical techniques, new animal models, new implantable materials and prostheses, and a combination of innovative imaging techniques and surgical instruments and procedures. Local, national, and European expert teams and networks are increasingly supporting these developments in order to address medical issues covering the whole lifespan from prenatal and postnatal anomalies until old age. The theme RRM has as its common denominator reconstructive and regenerative medicine for individualized personal healthcare and treatment innovation. Within the RRM theme, research is centered around three main lines of research for the future, as a result of  a strategy and focus process in 2017.
 

Objectives

  • We will investigate clinical applications for musculoskeletal diseases.
  • We will investigate applications for kidney diseases.
  • We are investigating applications for the urogenital tract.
  • We are looking for applications for skin diseases.
  • We are investigating reconstructive surgical procedures and TERM applications.

Theme leader

Wout Feitz MD PhD
full professor

+31 (0)24 361 37 35

Contact

Lines of research



Surgeon of the future

Within this subtopic, research focuses on: (i) clinical expertise for complex problems and rare diseases in combination with basic and clinical research that will shape the future together with patients; (ii) with emerging robot- and data-driven techniques the focus is shifting to minimally invasive surgery (e.g. patient-tailored surgery through the use of advanced procedure planning and assistance by advanced imaging modalities and artificial intelligence; (iii) this constantly changing medical environment requires adaptation of daily clinical practice, and training of a new type of surgeon using new procedures and materials. Theme RRM uses the concept of the ‘Surgeon of the future’ and develops and implements technologies that revolutionize surgical procedures, including patient-specific virtual operation planning, 3D-printed anatomical models, simulated reconstructions, new animal models for surgical procedures and material evaluation, and the use of augmented reality.
 


Materials to support self-healing

The research within this line focuses on: (i) cell-free implants and prostheses; (ii) functionalized material and smart scaffolds; (iii) 3D technologies. While the human body already contains an extraordinary capacity for natural self-repair, the removal of diseased or damaged tissues, organs, and body parts results in both physical ‘gaps’ and defects in function and appearance that need to be restored. Our theme develops tools that support and instruct the body’s endogenous healing and regenerative capacity to replace structural anomalies and lost or damaged tissues, which includes prosthetic tools, smart and patient-tailored scaffolds, implants, and biomaterials. The theme aims to apply acellular biomaterials (where possible) or intra-operatively prepared cellular constructs as these are easier to translate to the clinic than complex biomaterials.
 


Regrowing tissues, organs and limbs

Here research includes: (i) functional tissue regeneration; (ii) organ regeneration; (iii) limb reconstructions. Self-healing is the regeneration of functional tissues and organs. In Europe, thousands of people are on a waiting list for organ transplantation (e.g. heart, kidney, liver, lungs), and often die prior to organ transplantation because of the shortage in healthy donor organs and the difficulty in finding a good match. Theme RRM combines expertise towards making several essential steps to fulfil the true potential of reconstructive and regenerative medicine. The theme combines all necessary know-how to take a leading position in functional restoration of underdeveloped tissues and missing limbs. Working towards normal functional outcome of limb replacement and additional innovations in a realistic matter.

 

News and agenda

Organisation


Coordinating team

The daily management of the theme Reconstructive & Regenerative Medicine is executed by the coordinating team.

see members

Coordinating team

The daily management of the theme Reconstructive & Regenerative Medicine is executed by the coordinating team, consisting of the following members:
 
Wout Feitz (Urology, chair)
Nico Verdonschot (Orthopedics)
Willeke Daamen (Biochemistry)
Jeroen van den Beucken (Biomaterials)
Dov Ballak (scientific policy advisor)

European Reference Networks

The theme is linked to the European Reference Networks.


Answers in Dutch

Information on our research can also be found in Dutch on the Nationale Wetenschapsagenda website. The information here answers questions asked by Dutch citizens.

Research group leaders

Affiliated institutes and centers

Radboud Institute for Health Sciences

Ideally, every procedure in clinical practice and public health should take place based on proof, instead of intuition or 'experience'. Our aim is to improve clinical practice and public health.

Radboud Institute for Molecular Life Sciences

Our main aim is to achieve a greater understanding of the molecular mechanisms of disease. By integrating fundamental and clinical research, we obtain multifaceted knowledge of (patho)physiological processes. read more

Radboudumc Technology Center 3D lab

The focus in the 3D Lab is how we can use 3D technologies to improve care for each individual patient. These new technologies help improve the care and the treatment plan of patients, while taking their specific individual needs and wishes into consideration.

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Radboudumc Technology Center Stem cells

The Radboudumc Technology Center for Stem Cells provides a state-of-the-art service to reprogram skin-derived fibroblasts into iPSCs.

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Radboudumc Technology Center Animal research facility

This technology center offers advice and support from planning up to and including the conduct of animal research on behalf of biomedical research and education.

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Radboudumc Technology Center Clinical studies

Radboudumc provides professional support in the conduct of clinical research involving human subjects.

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