News

Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

Bart Smeets, Jitske Jansen and collegues, theme Renal disorders published this article in the Human Development.

ERC Starting Grant awarded to Jeroen de Baaij

Jeroen de Baaij, kidney researcher the Radboudumc, receives an ERC Starting Grant worth 1.5 million euros. He will use this grant to improve the diagnosis and treatment of severe magnesium deficiencies, which can lead to epileptic seizures and muscle cramps.

Research on the development of kidneys in prematurely born children

Michiel Schreuder, together with Maastricht UMC+, is now starting a study into the kidneys of these children. For this, the researchers received a grant from the Kidney Foundation. 

Laurens Verscheijden awarded doctorate degree 'cum laude'

Laurens Verscheijden of the Department of Pharmacology and Toxicology, defended his PhD thesis, entitled "Mechanistic models for the prediction of brain drug exposure and response in the paediatric population: A virtual child reaching maturation.

Kidney damage as a result of coronavirus infection Coronavirus infects the kidneys and contributes to tissue scarring

Johan van der Vlag chairs Scientific Advisory Board Mercurna

Johan van der Vlag will strengthen the development path of mCura1, Mercurna's lead formulation for chronic kidney disease as chair of the Scientific Advisory Board of the Biotech.

Academic collaboration agreement between UTwente and Radboudumc

The group of Biomaterials Science and Technology (BST) of the Faculty of Science and Technology at the TechMed centre of University of Twente has signed a formal academic collaboration agreement with the departments of Nephrology and Physiology at Radboudumc.

Determining fluid balance of patients by measuring electrical body resistance

PhD research Jantine Jansen-Schotman offers starting points for better analysis.

Raphaël Duivenvoorden winner of Publication Awards 2020

Recently, during the Dutch Nephrology Days, the Publication Awards 2020 was given by the Dutch federation for Nephrology (NFN).

Frans Russel appointed member Supervisory Committee of RIVM

Frans Russel, theme Renal disorders, has been appointed by The Minister of Health, Welfare and Sport (VWS).

RIMLS awards call for nominations

RIMLS awards several prizes to stimulate and honor our (young) researchers. Upcoming awards are Supervisor of the Year, Best Master Thesis, Best Publication, Best Image and more. Send your nominations now before 24 November 2021.

Genetic mutations cause severe magnesium deficiency

Newly discovered errors in DNA change diagnostics and treatment. Jeroen de Baaij tracked down new genetic errors that cause magnesium deficiency and published the findings in the Journal of the American Society of Nephrology.

Tom Nijenhuis appointed professor of Rare Kidney Diseases

Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias

Lia Goltstein and colleagues published a study about effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis.

Consortium grant Dutch Kidney Foundation for ArtDECO consortium

The Dutch Kidney Foundation awarded a consortium grant of 1.5M euros to the ArtDECO consortium, >400K euros of which will be allocated to the Radboudumc and more specifically to the AGORA data- and biobank.

Genetic diagnosis in hereditary hemochromatosis discovering and understanding the biological relevance of variants

Floor Baas and Dorine Swinkels, theme Renal Disorders, published about assessment of pathogenicity of genetic variants in hereditary hemochromatosis.

Jeroen de Baaij Appointed associate professor

We are happy to announce that Jeroen de Baaij has been appointed associate professor of Kidney Physiology.

Senior Kolff Fellowship for Jeroen de Baaij

Jeroen de Baaij, theme Renal disorders, received a prestigious Senior Kolff grant from the Dutch Kidney Foundation. His project aims to establish dietary approaches against vascular calcification in chronic kidney disease.

Christa Sperna Weiland, Erwin van Geenen and Joost Drenth discuss the best strategy to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis

Christa Sperna Weiland, Erwin van Geenen and Joost Drenth, published in Lancet Gastroenterology & Hepatology a systematic review and network meta-analysis to determine the most efficacious prophylaxis strategy to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis.

Finding better ways to diagnose and treat IgA nephropathy

IgA nephropathy is a slowly progressing disease that causes kidney damage and leads to kidney failure in about 25-50% of patients. The reason why some people develop IgA nephropathy is unclear and there is no effective treatment.

Magnesium deficiency increases the risk of cardiovascular disease in diabetic patients

Publication in Diabetes Care.

Aggressive periprocedural hydration + rectal NSAID: no reduction in incidence of post-ERCP pancreatitis

Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial.

4th ENABLE symposium a big success

RIMLS PhD candidates co-organized this unique event with three other European research institutes (IRB Barcelona, CPR Copenhagen, SEMM Milan), which was facilitated by a competitive Horizon 2020 grant.

Lisanne Gommers nominated for James Lind Prize Your vote is needed

Her PhD research entitled "Digesting the role of the gut microbiome in proton pump inhibitor (PPI)-induced hypomagnesemia'' has been nominated for the James Lind Prize. You can vote now until 8 June.

Miniaturized microfluidic platform for automated epigenetic profiling

Together with Fluidigm, a US-based company focusing on microfluidics, the team of Hendrik Marks publishes in Genome Research the development of a powerful plug and play ChIP-seq platform for minute amount of cells, such as embryonic specimens or small biopsies.

Dutch Children's Formulary now also in use abroad Drug database for pediatric dosing available online for German, Austrian and Norwegian physicians

The Kinderformularium, developed in the Netherlands, now also provides pediatricians and pharmacists abroad with a database of drug dosage recommendations specifically aimed at treating children.

Embryonic development and magnesium homeostasis is regulated by Cyclin M2

Gijs Franken and colleagues, theme Renal disorders, published in Scientific Reports that Cyclin M2 (CNNM2) is vital for embryonic development and magnesium homeostasis.

E-learning avoids gastroscopy in patients with stomach complaints

Many patients with stomach complaints who are referred for a gastroscopy actually do not need that unpleasant examination. Thanks to an e-learning module, they become more aware of their complaints and many of them refrain from such an examination.

Cross communication between nephron segments by extracellular vesicles

In the FASEB Journal, Joost Hoenderop and other researchers, theme Renal disorders, demonstrated that purinergic signaling and αENaC mRNA expression is controlled by extracellular vesicles flowing along the nephron segments.

Bifunctional protein PCBD2 operates as a co‐factor for hepatocyte nuclear factor 1β and modulates gene transcription.

Lotte Tholen, theme Renal disorders, and colleagues published in the FASEB Journal that PCBD1 and PCBD2 exert different effects on HNF1β‐mediated transcription.

Bifunctional protein PCBD2 operates as a co‐factor for hepatocyte nuclear factor 1β and modulates gene transcription.

Lotte Tholen, theme Renal disorders, and colleagues published in the FASEB Journal that PCBD1 and PCBD2 exert different effects on HNF1β‐mediated transcription.

Michiel Schreuder appointed Professor of Pediatric Nephrology

Michiel Schreuder appointed full professor of Pediatric Nephrology as of 16 January 2021.

Iron Expertise Center will be transferred from Radboudumc to Sanquin

The strong connection with Radboudumc will be maintained by current head of the expertise center Dorine Swinkels, who will be employed by both Sanquin and Radboudumc.

Discovery of new protein with an important role in atherosclerosis

Atherosclerosis is the underlying condition that causes heart attacks and strokes. Researchers at Radboudumc in the Netherlands have discovered a protein that appears to play an important role in atherosclerosis. The protein is called Prosaposin.

Academic Alliance Fund (AAF) grant for Cansu Yanginlar and Johan van der Vlag

They received 100 kEuro for their project “NETworking: Deciphering the pathologic properties of the neutrophil in COVID-19, ANCA-associated vasculitis (AAV), and systemic lupus erythematosus (SLE).

Dutch Kidney Foundation Innovation Grant for Tom Nijenhuis and Jeroen de Baaij

This innovation grant was awarded for their project “A sweet deal: repurposing SGLT2i for renal hypomagnesemia”.

Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes Joubert syndrome

Brooke L. Latour, theme renal disorders, published an interesting article on the cause of the Joubert syndrome in the Journal of Clinical Investigation.

Marie Curie Fellowship for Juan Pablo Rigalli

RIMLS postdoc Juan Pablo Rigalli, theme Renal disorders, is awarded with a Marie Curie Fellowship from the European Commission to study the application of extracellular vesicles in precision pharmacotherapy.

ZonMw grants to study optimal use of COVID-19 vaccines in patients with impaired immune systems

How do people with reduced immunity, especially kidney patients, react to a COVID-19 vaccination? And how can patients with peripheral arterial disease be helped by DNA testing? Our researchers received grants from ZonMw to make these studies possible.

RIMLS online award ceremony proudly presenting the winners

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony. 

Dutch Digestive Foundation grant for Joost Drenth

Joost Drenth, theme Renal disorders, received a Dutch Digestive Foundation grant in cooperation with his colleagues from Amsterdam UMC and Leiden UMC.

A better understanding of iron deficiency with new insights

Dorine Swinkels, together with her colleagues, provides scientific evidence-based guidance on how iron deficiency should be diagnosed and treated to ensure positive health effects over time.

Vote for the Supervisor of the year

Now you have the chance to vote for your preferred candidate. Have fun, and go for it, support and promote your ideal supervisor. Please submit your vote at the latest 4 January 2021.

COVID-19 and the kidney overview of papers

Within the research theme Renal Disorders several studies were initiated to contribute to the knowledge on COVID-19. Check out our overview of the papers that originated from these studies.

Hydroxychloroquine against malaria appears to block 'trained immunity'

Raphaël Duivenvoorden and colleagues have discovered an as yet unknown effect of hydroxychloroquine, which are published in Cell Reports Medicine.

Multiple prizes for nephrological researchers

A rain of prizes was awarded to colleagues from the research theme Renal Disorders during the combined Dutch Nephrology Days and Scientific Fall symposium of the Dutch Federation for Nephrology (NFN).

The best thesis prize 2019 within Nephrology awarded to Kioa Wijnsma

Kioa Wijnsma, theme Renal disorders, won the best thesis award 2019 within Nephrology

Transfer of new anti-hepatitis C drugs across the human placenta

In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.

Safer and more effective use of medicines in children How 'virtual children' will make a difference

The efficacy and safety of about half of all drugs prescribed to children has not been adequately researched. Because growth and development change the way a child's body deals with drugs, it runs an increased risk of receiving ineffective or unsafe drugs.

Molecular scissors play a role in kidney and lung leakage in COVID-19 patients

‘Molecular scissors', play a role in leakage of fluid from blood vessels to lungs and kidneys in COVID-19 patients. The scissors cut the protective sugar layer in the blood vessels. The more serious the disease, the more active the scissors, wrote Johan van der Vlag and colleagues in MedRxiv.