News - Radboudumc

The following news items are related to the research Vascular damage.

Exercise prevents new cardiovascular diseases

4 March 2021

Exercise lowers the risk of glucose intolerance, obesity, elevated cholesterol and hypertension. The risk of new cardiovascular diseases can be lowered by an individual exercise guideline, argues epidemiologist Esmée Bakker in her dissertation on March 4.

Arterial wall inflammation and increased hematopoietic activity in patients with primary aldosteronism

4 March 2021

Niels Riksen and colleagues identified increased inflammatory activity in patients with primary aldosteronism.

Water as a new tool for cardiac screening for chest pain

2 March 2021

Patients with chest pain not caused by a narrowing of the coronary arteries often do not know the cause of their symptoms. Scientists at the Radboudumc have successfully used a new technique to investigate other causes in the coronary arteries of the heart.

Reducing sitting time improves blood flow in the brain and in the legs

2 March 2021

During a regular day, the average person sits for 8-10 hours. These high levels of sitting time seem linked to an increased risk for both cardiovascular and cerebrovascular diseases.

We are getting less physically active due to the coronavirus pandemic

16 February 2021

“If exercise was available in the form of a pill, it would be the most commonly prescribed drug in the world.”

Pregnancy complications and early menopause affect cardiovascular disease in women

9 February 2021

A number of specific conditions in women are important in their risk of cardiovascular disease. These include high blood pressure during pregnancy, gestational diabetes and early menopause.

RIMLS online award ceremony proudly presenting the winners

13 January 2021

In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.

Reprogramming of bone marrow myeloid precursor cells in patients with severe coronary artery disease

10 November 2020

Exploratory ''first-in-man'' study adds a new dimension to the role of our innate immune system in the development of cardiovascular disease. This study from Niels Riksen and colleagues is published in Elife.

Cum Laude PhD defense for Vincent Aengevaeren

29 October 2020

We congratulate Vincent Aengevaeren! After defending his thesis entitled: ‘Potential Detrimental Effects of Exercise on the Heart’ on 28 October, Vincent attained his PhD degree with honors. Vincent had been appointed on a RIHS Junior Researcher grant.

Dora the explorer: exploring new ways of recognition and reward in science Blog by Siroon Bekkering

27 October 2020

This blog by Siroon Bekkering, theme Vascular Damage, is a great way to draw more attention to the discussion around recognition and reward.

Centuries-old medicine reduces the risk of new cardiovascular disease in heart patients

17 September 2020

Colchicine, an anti-inflammatory drug that has been used for gout for centuries, has been shown to prevent cardiovascular disease in patients who have had a heart attack or are suffering from narrowed coronary arteries. Results of the study are published in the New England Journal of Medicine.

Can a change in lifestyle relieve heart cramps?

10 September 2020

Cardiac spasm, or angina pectoris, is a common heart condition. Even though these patients are well monitored and treated, they are still at risk of more severe heart failure.

Transfer of new anti-hepatitis C drugs across the human placenta

9 September 2020

In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.

Long-term and acute benefits of reduced sitting on vascular flow and function

31 August 2020

In Medicine and Science in Sports and Exercise Yvonne Hartman described a 16-week reduced sitting intervention that improved vascular function and cerebral blood flow. This highlights the potential benefits of reducing sedentary behaviour to improve cardio- or cerebrovascular risk.

Cardiac rehabilitation has a positive impact on the life expectancy of cardiac patients

27 August 2020

All cardiovascular patients can benefit from participation in a cardiac rehabilitation program. People who participate in a program, in which they gain more knowledge about risk factors for cardiovascular disease and receive advice about lifestyle and stress management, live longer on average.

Cardiac function in relation to myocardial injury in hospitalised patients with COVID-19

16 July 2020

In Netherlands Heart Journal RIHS researcher Frederik van den Heuvel described that in hospitalized COVID-19 patients, COVID-19 predominantly affects the respiratory system, while cardiac dysfunction occurs less often.

Jan Hein Cornel and Robert-Jan van Geuns appointed as full Professors of Cardiology

18 June 2020

On 1 April, two new professors were added to the Cardiology department. Jan Hein Cornel has been named by special appointment as professor of Inflammation in Atherosclerotic Cardiovascular Disease, and Robert-Jan van Geuns has been appointed as the new professor of Interventional Cardiology.

Cooling strategies for COVID-19 health personnel to attentuate PPE-induced heat strain

11 June 2020

Radboudumc develops infographic with cooling information

Set7 regulates enhanced cytokine production in trained immunity in vitro

28 April 2020

Postdoc Sam Keating and colleagues from the group of Niels Riksen, theme Vascular damage, revealed Set7 as a key regulator of trained immunity. They have published their findings in Cell Reports.

Marc Spaanderman appointed Professor of Obstetrics

16 April 2020

Marc Spaanderman has been appointed Professor of Obstetrics at Radboud University/ Radboud university medical center, with effect from 1 March 2020.

Catecholamines induce trained immunity in monocytes in vitro and in vivo

10 April 2020

Niels Riksen and colleagues contributed data in Circulation Research, to the understanding of pathways driving inflammatory changes in conditions characterized by high catecholamine levels, and proposed that trained immunity underlies the increased cardiovascular event rate in PHEO patients.

RIMLS PhD retreat registration is open

23 January 2020

Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.

Mohrmann Stipend for Bakker and Peters

12 December 2019

Tuesday 10 December, Esmée Bakker and Yonne Peters were awarded a Christine Mohrmann stipend. The grant – 5000 euros each – gives them an opportunity to spend time at another university, preferably one abroad.

Dietrich-Knorr Prize for Hedi Claahsen-van der Grinten

10 December 2019

Hedi Claahsen-van der Grinten, theme Vascular damage, received the Dietrich-Knorr prize 2019 for the best published paper in the field of adrenal research, for her publication in the Journal of Clinical Endocrinology & Metabolism.

Dutch National Postdoc award for Siroon Bekkering

29 November 2019

Siroon Bekkering, theme Vascular damage, will use the prize money (€10,000) for her follow-up research into the memory of the innate immune system of patients with cardiovascular diseases.

Dekker personal grants call for proposals

28 November 2019

These personal grants are intended for talented (clinical) investigators in the field of cardiovascular research. The deadline for submission is 4 February 2020.

Knowledge translation in health how implementation science could contribute more

28 November 2019

In BMC Medicine Michel Wensing and Richard Grol reflect on the development of implementation science in health in the previous decade and give recommendations for how it could contribute more.

RIMLS awards call for nominations

26 November 2019

RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.

3D breast ultrasound elastography to improve breast cancer detection

5 November 2019

One out of seven women will be diagnosed with breast cancer during their life. Early detection of breast cancer is important to increase the survival rate. Gijs Hendriks graduated recently on a new technique, 3D elastography, to detect breast cancer better.

RIMLS 25 years jubilee festival The Future is Yesterday

3 October 2019

Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...

The effect of an invasive approach on final infarct size and clinical outcome up to 1 year

24 September 2019

Niels van Royen published in JACC: Cardiovascular Interventions, that patients with transient STEMI have limited infarction and well-preserved myocardial function in general, and delayed or immediate revascularization has no effect on functional outcome and clinical events up to 1 year.

Healthy weight limits risk of dementia even in old age

17 September 2019

Even late in life it makes sense to maintain a healthy weight, and thus to limit the risk of cognitive decline.

RIMLS PhD grants awarded to eight RIMLS (j)PI's

12 September 2019

Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects.

More than 350 festival attendees learned CPR during the Lowlands Saves Lives trial

26 August 2019

During the 2019 Lowlands music festival, the Lowlands Saves Lives trial was performed by the department of Cardiology. The study was a huge success as over 350 participants were randomized and learned to perform CPR.

Circulation publication for exercise physiologists

13 August 2019

Thijs Eijsvogels and Vincent Aengevaeren showed that exercise-incuded elevations of troponin concentrations are predictive of major adverse cardiovascular events and mortality.

Floris Schreuder received Dekker grant

6 August 2019

Floris Schreuder received one of the ten Dekker grants from the Dutch Heart Foundation (Hartstichting).

Robin Nijveldt appointed Professor of Cardiovascular Imaging

1 July 2019

Robin Nijveldt was appointed Professor of Cardiovascular Imaging at Radboudumc, with effect from 1 June 2019. Nijveldt is an expert in the field of cardiac imaging and cardiac MRI in particular, with a focus on coronary artery disease and cardiomyopathies.

Remote Ischemic Conditioning as a new treatment for ischemic stroke

20 June 2019

In Stroke Thijs Landman and colleagues described the existing clinical and preclinical evidence for a new non-invasive treatment in patients with an ischemic stroke: Remote Ischemic Conditioning.

Lowering cholesterol is not enough to reduce hyperactivity of the immune system

14 June 2019

In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provide a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.

NWO grant 900,000 euros for Chris de Korte

30 April 2019

Chris obtained an Open Technology Program (OTP) grant from NWO Engineering and Applied Sciences for his work on vascular flow imaging using ultrasound.

The impact of Transradial Intervention (TRI) on digital hand perfusion

29 April 2019

Niels van Royen, theme Vascular damage, and colleagues, investigated the effect of TRI on digital perfusion by laser doppler perfusion imaging. They concluded in Circulation: Cardiovascular Interventions, that TRI is safe.

Three Royal decorations for RIHS researchers

29 April 2019

Peter de Smet, Harry Surayapranata and Stans Verhagen received royal honours for their exceptional academic and social achievements.

Coronary angiography after cardiac arrest without ST-segment elevation

2 April 2019

Niels van Royen, theme Vascular damage, found out and published in NEJM, that among patients who had been successfully resuscitated after out-of-hospital cardiac arrest and had no signs of STEMI, a strategy of immediate angiography was not found to be better than a strategy of delayed angiography.

TART in congenital adrenal hyperplasia: current insights

1 April 2019

Hedi Claahsen and colleagues, theme Vascular damage, provide in Endocrine Reviews current insights on testicular adrenal rest tumors (TARTs),

Call for RIMLS Junior Researcher 2020

24 March 2019

In 2020 funding will be made available for 8 RIMLS Junior Researcher projects. The call for these PhD grants is now open.

Protein supplementation improves lean body mass in physically active older adults

21 March 2019

In the Journal of Cachexia, Sarcopenia & Muscle, Dominique ten Haaf and colleagues described a randomized clinical trial to assess the effects of 12-weeks protein supplementation on body characteristics.

Proudly presenting new theme leaders

20 March 2019

It is our pleasure to introduce the new leaders of the themes Mitochondrial diseases, Reconstructive and regenerative medicine and Vascular damage.

A personal touch of Hedi Claahsen

17 March 2019

In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Hedi Claahsen.

Higher prevalence of coronary atherosclerosis among runners versus cyclists

14 March 2019

Physical activity and exercise training are effective strategies to reduce the risk for cardiovascular events, but researchers from Radboudumc, UMC Utrecht and Meander MC previously found a higher burden of coronary atherosclerosis among the most active athletes.

Dekker grant for Siroon Bekkering

28 January 2019

Siroon Bekkering, theme Vascular damage, obtained a Dekker grant of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'. And follow her vlog.

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