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Exercise lowers the risk of glucose intolerance, obesity, elevated cholesterol and hypertension. The risk of new cardiovascular diseases can be lowered by an individual exercise guideline, argues epidemiologist Esmée Bakker in her dissertation on March 4.
Niels Riksen and colleagues identified increased inflammatory activity in patients with primary aldosteronism.
Patients with chest pain not caused by a narrowing of the coronary arteries often do not know the cause of their symptoms. Scientists at the Radboudumc have successfully used a new technique to investigate other causes in the coronary arteries of the heart.
During a regular day, the average person sits for 8-10 hours. These high levels of sitting time seem linked to an increased risk for both cardiovascular and cerebrovascular diseases.
“If exercise was available in the form of a pill, it would be the most commonly prescribed drug in the world.”
A number of specific conditions in women are important in their risk of cardiovascular disease. These include high blood pressure during pregnancy, gestational diabetes and early menopause.
In this special webinar of the RIMLS New Year Celebration, scientific director René Bindels reviewed 2020 and looked forward to 2021. But more importantly a number of researchers received prizes in the traditional RIMLS awards ceremony.
Exploratory ''first-in-man'' study adds a new dimension to the role of our innate immune system in the development of cardiovascular disease. This study from Niels Riksen and colleagues is published in Elife.
We congratulate Vincent Aengevaeren! After defending his thesis entitled: ‘Potential Detrimental Effects of Exercise on the Heart’ on 28 October, Vincent attained his PhD degree with honors. Vincent had been appointed on a RIHS Junior Researcher grant.
This blog by Siroon Bekkering, theme Vascular Damage, is a great way to draw more attention to the discussion around recognition and reward.
Colchicine, an anti-inflammatory drug that has been used for gout for centuries, has been shown to prevent cardiovascular disease in patients who have had a heart attack or are suffering from narrowed coronary arteries. Results of the study are published in the New England Journal of Medicine.
Cardiac spasm, or angina pectoris, is a common heart condition. Even though these patients are well monitored and treated, they are still at risk of more severe heart failure.
In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.
In Medicine and Science in Sports and Exercise Yvonne Hartman described a 16-week reduced sitting intervention that improved vascular function and cerebral blood flow. This highlights the potential benefits of reducing sedentary behaviour to improve cardio- or cerebrovascular risk.
All cardiovascular patients can benefit from participation in a cardiac rehabilitation program. People who participate in a program, in which they gain more knowledge about risk factors for cardiovascular disease and receive advice about lifestyle and stress management, live longer on average.
In Netherlands Heart Journal RIHS researcher Frederik van den Heuvel described that in hospitalized COVID-19 patients, COVID-19 predominantly affects the respiratory system, while cardiac dysfunction occurs less often.
On 1 April, two new professors were added to the Cardiology department. Jan Hein Cornel has been named by special appointment as professor of Inflammation in Atherosclerotic Cardiovascular Disease, and Robert-Jan van Geuns has been appointed as the new professor of Interventional Cardiology.
Radboudumc develops infographic with cooling information
Postdoc Sam Keating and colleagues from the group of Niels Riksen, theme Vascular damage, revealed Set7 as a key regulator of trained immunity. They have published their findings in Cell Reports.
Marc Spaanderman has been appointed Professor of Obstetrics at Radboud University/ Radboud university medical center, with effect from 1 March 2020.
Niels Riksen and colleagues contributed data in Circulation Research, to the understanding of pathways driving inflammatory changes in conditions characterized by high catecholamine levels, and proposed that trained immunity underlies the increased cardiovascular event rate in PHEO patients.
Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.
Tuesday 10 December, Esmée Bakker and Yonne Peters were awarded a Christine Mohrmann stipend. The grant – 5000 euros each – gives them an opportunity to spend time at another university, preferably one abroad.
Hedi Claahsen-van der Grinten, theme Vascular damage, received the Dietrich-Knorr prize 2019 for the best published paper in the field of adrenal research, for her publication in the Journal of Clinical Endocrinology & Metabolism.
Siroon Bekkering, theme Vascular damage, will use the prize money (€10,000) for her follow-up research into the memory of the innate immune system of patients with cardiovascular diseases.
These personal grants are intended for talented (clinical) investigators in the field of cardiovascular research. The deadline for submission is 4 February 2020.
In BMC Medicine Michel Wensing and Richard Grol reflect on the development of implementation science in health in the previous decade and give recommendations for how it could contribute more.
RIMLS awards several prizes to stimulate and honor our (young) researchers. Please find here an overview of the upcoming awards. Deadline 12 December 2019.
One out of seven women will be diagnosed with breast cancer during their life. Early detection of breast cancer is important to increase the survival rate. Gijs Hendriks graduated recently on a new technique, 3D elastography, to detect breast cancer better.
Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
Niels van Royen published in JACC: Cardiovascular Interventions, that patients with transient STEMI have limited infarction and well-preserved myocardial function in general, and delayed or immediate revascularization has no effect on functional outcome and clinical events up to 1 year.
Even late in life it makes sense to maintain a healthy weight, and thus to limit the risk of cognitive decline.
Recently, RIMLS held an internal call for Radboudumc junior researcher (PhD) positions. Congratulations for all the awardees and all the best in conducting the research projects.
During the 2019 Lowlands music festival, the Lowlands Saves Lives trial was performed by the department of Cardiology. The study was a huge success as over 350 participants were randomized and learned to perform CPR.
Thijs Eijsvogels and Vincent Aengevaeren showed that exercise-incuded elevations of troponin concentrations are predictive of major adverse cardiovascular events and mortality.
Floris Schreuder received one of the ten Dekker grants from the Dutch Heart Foundation (Hartstichting).
Robin Nijveldt was appointed Professor of Cardiovascular Imaging at Radboudumc, with effect from 1 June 2019. Nijveldt is an expert in the field of cardiac imaging and cardiac MRI in particular, with a focus on coronary artery disease and cardiomyopathies.
In Stroke Thijs Landman and colleagues described the existing clinical and preclinical evidence for a new non-invasive treatment in patients with an ischemic stroke: Remote Ischemic Conditioning.
In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provide a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.
Chris obtained an Open Technology Program (OTP) grant from NWO Engineering and Applied Sciences for his work on vascular flow imaging using ultrasound.
Niels van Royen, theme Vascular damage, and colleagues, investigated the effect of TRI on digital perfusion by laser doppler perfusion imaging. They concluded in Circulation: Cardiovascular Interventions, that TRI is safe.
Peter de Smet, Harry Surayapranata and Stans Verhagen received royal honours for their exceptional academic and social achievements.
Niels van Royen, theme Vascular damage, found out and published in NEJM, that among patients who had been successfully resuscitated after out-of-hospital cardiac arrest and had no signs of STEMI, a strategy of immediate angiography was not found to be better than a strategy of delayed angiography.
Hedi Claahsen and colleagues, theme Vascular damage, provide in Endocrine Reviews current insights on testicular adrenal rest tumors (TARTs),
In 2020 funding will be made available for 8 RIMLS Junior Researcher projects. The call for these PhD grants is now open.
In the Journal of Cachexia, Sarcopenia & Muscle, Dominique ten Haaf and colleagues described a randomized clinical trial to assess the effects of 12-weeks protein supplementation on body characteristics.
It is our pleasure to introduce the new leaders of the themes Mitochondrial diseases, Reconstructive and regenerative medicine and Vascular damage.
In order to promote interaction amongst colleagues within RIMLS, we have a ‘personal touch’ series setting employees in the spotlight. A light-hearted manner to learn about the colleagues you know and those you don’t! This week: Hedi Claahsen.
Physical activity and exercise training are effective strategies to reduce the risk for cardiovascular events, but researchers from Radboudumc, UMC Utrecht and Meander MC previously found a higher burden of coronary atherosclerosis among the most active athletes.
Siroon Bekkering, theme Vascular damage, obtained a Dekker grant of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'. And follow her vlog.
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