Reprogramming of bone marrow myeloid precursor cells in patients with severe coronary artery disease10 November 2020
Exploratory ''first-in-man'' study adds a new dimension to the role of our innate immune system in the development of cardiovascular disease. This study from Niels Riksen and colleagues is published in Elife.
Cum Laude PhD defense for Vincent Aengevaeren29 October 2020
We congratulate Vincent Aengevaeren! After defending his thesis entitled: ‘Potential Detrimental Effects of Exercise on the Heart’ on 28 October, Vincent attained his PhD degree with honors. Vincent had been appointed on a RIHS Junior Researcher grant.
Centuries-old medicine reduces the risk of new cardiovascular disease in heart patients17 September 2020
Colchicine, an anti-inflammatory drug that has been used for gout for centuries, has been shown to prevent cardiovascular disease in patients who have had a heart attack or are suffering from narrowed coronary arteries. Results of the study are published in the New England Journal of Medicine.
Transfer of new anti-hepatitis C drugs across the human placenta9 September 2020
In a recent publication in American Journal of Obstetrics and Gynecology, researchers from the Departments of Pharmacology and Toxicology, Pharmacy, Obstetrics and Gynecology, Gastroenterology and Hepatology, investigated the placental passage of two such drugs for the first time.
Long-term and acute benefits of reduced sitting on vascular flow and function31 August 2020
In Medicine and Science in Sports and Exercise Yvonne Hartman described a 16-week reduced sitting intervention that improved vascular function and cerebral blood flow. This highlights the potential benefits of reducing sedentary behaviour to improve cardio- or cerebrovascular risk.
Cardiac rehabilitation has a positive impact on the life expectancy of cardiac patients27 August 2020
All cardiovascular patients can benefit from participation in a cardiac rehabilitation program. People who participate in a program, in which they gain more knowledge about risk factors for cardiovascular disease and receive advice about lifestyle and stress management, live longer on average.
Cardiac function in relation to myocardial injury in hospitalised patients with COVID-1916 July 2020
In Netherlands Heart Journal RIHS researcher Frederik van den Heuvel described that in hospitalized COVID-19 patients, COVID-19 predominantly affects the respiratory system, while cardiac dysfunction occurs less often.
Jan Hein Cornel and Robert-Jan van Geuns appointed as full Professors of Cardiology18 June 2020
On 1 April, two new professors were added to the Cardiology department. Jan Hein Cornel has been named by special appointment as professor of Inflammation in Atherosclerotic Cardiovascular Disease, and Robert-Jan van Geuns has been appointed as the new professor of Interventional Cardiology.
Catecholamines induce trained immunity in monocytes in vitro and in vivo10 April 2020
Niels Riksen and colleagues contributed data in Circulation Research, to the understanding of pathways driving inflammatory changes in conditions characterized by high catecholamine levels, and proposed that trained immunity underlies the increased cardiovascular event rate in PHEO patients.
RIMLS PhD retreat registration is open23 January 2020
Yearly, RIMLS PhD candidates gather for the two-day PhD Retreat. Apart from the science, this event is highly valued for the opportunity to meet and get to know fellow PhD candidates during the social activities. Early bird registration and abstract submission deadline: 4 March 2020.
Dietrich-Knorr Prize for Hedi Claahsen-van der Grinten10 December 2019
Hedi Claahsen-van der Grinten, theme Vascular damage, received the Dietrich-Knorr prize 2019 for the best published paper in the field of adrenal research, for her publication in the Journal of Clinical Endocrinology & Metabolism.
3D breast ultrasound elastography to improve breast cancer detection5 November 2019
One out of seven women will be diagnosed with breast cancer during their life. Early detection of breast cancer is important to increase the survival rate. Gijs Hendriks graduated recently on a new technique, 3D elastography, to detect breast cancer better.
RIMLS 25 years jubilee festival The Future is Yesterday3 October 2019
Together with more than 250 colleagues and alumni we celebrated 25 years of research into the molecular mechanisms of disease. During this exciting and informal event, we not only took a trip down memory lane, but also looked ahead to the next 25 years and beyond…...
The effect of an invasive approach on final infarct size and clinical outcome up to 1 year24 September 2019
Niels van Royen published in JACC: Cardiovascular Interventions, that patients with transient STEMI have limited infarction and well-preserved myocardial function in general, and delayed or immediate revascularization has no effect on functional outcome and clinical events up to 1 year.
More than 350 festival attendees learned CPR during the Lowlands Saves Lives trial26 August 2019
During the 2019 Lowlands music festival, the Lowlands Saves Lives trial was performed by the department of Cardiology. The study was a huge success as over 350 participants were randomized and learned to perform CPR.
Robin Nijveldt appointed Professor of Cardiovascular Imaging1 July 2019
Robin Nijveldt was appointed Professor of Cardiovascular Imaging at Radboudumc, with effect from 1 June 2019. Nijveldt is an expert in the field of cardiac imaging and cardiac MRI in particular, with a focus on coronary artery disease and cardiomyopathies.
Lowering cholesterol is not enough to reduce hyperactivity of the immune system14 June 2019
In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provide a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.
The impact of Transradial Intervention (TRI) on digital hand perfusion29 April 2019
Niels van Royen, theme Vascular damage, and colleagues, investigated the effect of TRI on digital perfusion by laser doppler perfusion imaging. They concluded in Circulation: Cardiovascular Interventions, that TRI is safe.
Coronary angiography after cardiac arrest without ST-segment elevation2 April 2019
Niels van Royen, theme Vascular damage, found out and published in NEJM, that among patients who had been successfully resuscitated after out-of-hospital cardiac arrest and had no signs of STEMI, a strategy of immediate angiography was not found to be better than a strategy of delayed angiography.
Higher prevalence of coronary atherosclerosis among runners versus cyclists14 March 2019
Physical activity and exercise training are effective strategies to reduce the risk for cardiovascular events, but researchers from Radboudumc, UMC Utrecht and Meander MC previously found a higher burden of coronary atherosclerosis among the most active athletes.
Dekker grant for Siroon Bekkering28 January 2019
Siroon Bekkering, theme Vascular damage, obtained a Dekker grant of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'. And follow her vlog.
Quickly detecting actual heart attacks prevents unnecessary hospital visits Research by Radboud university medical center improves efficacy and reduces cost of cardiac care4 January 2019
Many patients who suffer from chest pain are not actually having a heart attack, making an emergency hospital visit unnecessary. Is there a way to quickly and accurately determine at home whether emergency hospital treatment is necessary?
Spontaneous coronary artery dissections and fibromuscular dysplasia27 November 2018
In the International Journal of Cardiology Angela Maas showed that spontaneous coronary artery dissections (SCADs) are increasingly recognized as an important cause of acute coronary syndromes in predominantly women below 60 years of age.