Vacancy Postdoc 'Point of care CAR-T cell production’

Job description

Interested in Immunology and Immunotherapy for cancer? Join our exciting translational research group! For our expanding translational research group we are looking for an ambitious Postdoc that is interested Advanced Therapy Medicinal Products and CAR-T cells.

As a Postdoc you will work together with researchers and (research)technicians to implement CAR-T cell manufacturing in our GMP facility to treat patients with diffuse large B-cell lymphoma. 

You will coordinate the implementation of the project and be involved in writing and reviewing GMP documentation, risk assessments, manufacturing and QC documentation. You will be part of our expert ATMP and QC team and be responsible for preparing batch records, deviations and change control in close collaboration with the Qualified Persons from the Pharmacy department. 

You will also actively be part of the production team involved in manufacturing of the CAR-T cells in our class B cleanroom environment, quality control testing and equipment and cleanroom monitoring and maintenance.  

You will be required to work on-site.

Place of work

You will work in the Immunotherapy research group of the Laboratory of Hematology, Department of Laboratory Medicine, Radboudumc, Nijmegen, the Netherlands. We focus on the characterization and modulation of anti-tumor immune responses in cancer patients.

Our translational research program encompasses three intermingled themes: 1) development of novel strategies to boost antitumor immunity after allogeneic stem cell transplantation, 2) development of CAR-T cell therapy against hematological cancers, and 3) innovative CAR-NK cell-based immunotherapy against leukemia and ovarian cancer. Our research is embedded in the Radboud Research Institute. The studies indicated in this vacancy will be performed in close collaboration with clinicians of the Department of Hematology at the Radboudumc. We provide a stimulating work environment within a group of enthusiastic non-clinical and clinical researchers with a strong national and international research network and track record.

You will workplace will vary between the office, class C and B cleanrooms and the research laboratory. 

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where our research groups strive for innovative solutions that make impact on health and healthcare. We challenge the status quo to overcome current and future health challenges. Our goal is to shape the future of healthcare for generations to come. Our focus is on prevention, sustainability, and meaningful care, which we achieve through our in-depth understanding of disease mechanisms, clinical science, public health research, medical technology and data science. Our approach is centered on breakthroughs that can truly enhance personalized healthcare and public health. 

At Radboudumc, a comprehensive range of research programs provide the compass for our research efforts. Each program has a clear goal, where collaboration within and outside our organization is highly valued. We integrate care, education and research in partnership with our patients to ensure that our research programs have significant impact on health and healthcare. We invite you to join us in our mission to create a healthy future for all.

Profile

This position requires you to have a Masters degree in (Medical) Biology, Biomedical sciences, Molecular life sciences, or similar. A PhD degree immunology / immuno therapy OR proven experience in quality and/or manufacturing in a GMP setting. You are pro-active, accurate, critical and flexible. You are social and have strong communication skills and are well structured and organized.

In addition you possess the profile below:

• Experience in cell culture, cellular immunology techniques, flow cytometry.
• Experience and affinity with GMP documentation and/or manufacturing.
• Experience and affinity with working an a cleanroom environment (preferably grade B).
• Able to work independantly as well as together with people from multiple disciplines (e.g. (research)Technicians, Scientists, Pharmacists, Doctors).
• A clear motivation to perform translational research.
• Affinity with cellular therapy.
• You can speak, write and read English (C1 or C2) and preferably Dutch (C1 or C2).

Employment conditions

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• A gross monthly salary between € 3.493 and € 5.504 (scale 10) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
• From 1 July 2025 an increase in salary with 3%.
• 176 vacation hours per year based on a 36-hour working week. 

And there is more..

• An Employment Conditions Selection Model, allowing you to use part of your employment conditions to your choosing. For example, you can use your gross salary to purchase additional vacation hours or hours for providing informal caregiving. Or, for example, you can use your gross end-of-year bonus to purchase a bicycle, so you pay less tax.
• Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment. 
• Your well-being and vitality are a priority. For example:
  • Save time for work-life balance leave. 
  • You can enjoy unlimited access to a variety of activities five days a month and take advantage of all the facilities at Radboud Sport & Culture for only €27.05 per month (instead of €41)
  • Healthy Professionals program to help you manage your energy. 
  • Company Support Team and a personal coach if you are going through a life-changing event.
  • Financially beneficial working less through a Generation Scheme as you approach state pension age.
• Support in achieving a good work-life balance at every stage of your life. Examples:
  • Advice and courses on, for example, 'Millennial dilemmas' and 'Your Career After 57'.
  • Activities at our own mindfulness center.
  • Informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
• In addition to statutory pregnancy and maternity leave, Radboud university medical center offers 26 weeks of parental leave, nine of which are paid. In addition, as a partner you can take a maximum of five weeks of supplementary partner leave. During supplementary partner leave and parental leave, we supplement the UWV benefit up to 100% of your salary.
• Pension accrual at the ABP Pension Fund. Radboud university medical center pays 70% of the pension premium. 
• Discounts on supplementary packages of two group health insurances and ten other types of insurance, from home insurance to legal assistance.
• An allowance for your commuting costs of € 0.18 per km up to a maximum of 40 km one way. If you use public transport to commute, we will fully reimburse the public transport costs (2nd class). If you regularly work from home, you will receive a working from home allowance of € 2.40 per day.

Application procedure

Are you ready to think further for our patients and our care? We would like to receive your application before 28 May 2025. We will then contact you shortly. The job interviews takes place in week 24. We would appreciate it if you would take this into account.

Good to know

• This position requires a Certificate of Conduct (VOG).
• You can find more information about our application procedure and frequently asked questions on our website.
• Will you be our new colleague? Then you will be given the time and space to get to know your role, your workplace, and your colleagues. An induction day for all new colleagues is an integral part of your onboarding program. 

We are recruiting for this position ourselves. Unsolicited marketing is not appreciated, but do feel free to share the vacancy in your network!

Contact

Any questions? Or wondering what it is like to work at Radboudumc? Then email to Harry Dolstra, Professor translational immunohematology. Use the Apply button to submit your application.