Preclinical Imaging Center
- A durable facility for small animals imaging with state of the art equipment and expertise.
- A facility with multi-modal equipment and offices integrated in one centre at one location.
- A centre that operates essentially as a SPF/DMII unit to allow experiments with transgenic animals and with adeno, retro and lenti-viruses.
- A centre with links to clinical/human imaging facilities.
ServicesThe infrastructure and imaging equipment in PRIME has some unique features under one roof in one facility:
- State-of-the-art scanners for: MRI, SPECT, PET, optical imaging, multiphoton microscopy, intrinsic optical imaging and ultrasound.
- Cognition and behavior rooms to measure (social) behavior learning and memory sensory-motor integration activity and motor skills.
- Barrier-free animal handling at safety level II allowing small animal studies with animals that can be infected with various agents (incl. adeno-/retroviruses, bacteria, parasites).
ContractPRIME also supports the pharmaceutical and biotechnology industries in the form of research services outsourced on a contract basis. The experts of PRIME can be involved in project development and consultancy as well as giving explanations on the use of our equipment. For more information you can contact Wilma Janssen.
PRIME and ...
PRIME is a facility that provides support to the pharmaceutical and biotechnology industries in the form of research services outsourced on a contract basis. read more
Contract Research Organization (CRO)The Preclinical Imaging Centre (PRIME) is a centralized facility for multimodality imaging of small animals, such as mice and rats. Multi modality imaging is a strategic technology, that can be used to support biopharmaceutical development and preclinical research.
PRIME is staffed by experts from various disciplines such as Radiology, Nuclear Medicine, Cell Biology, Medical Ultrasound Imaging Center, Anatomy and Cognitive Neuroscience. The infrastructure and imaging equipment in PRIME has some unique features under one roof in one facility:
- state-of-the-art scanners for: MRI, SPECT, PET, optical imaging, multiphoton microscopy , intrinsic optical imaging and ultrasound.
- cognition and behavior rooms to measure (social) behavior learning and memory sensory-motor integration activity and motor skills.
- barrier-free animal handling at safety level II allowing small animal studies with animals that can be infected with various agents (incl. adeno-/retroviruses, bacteria, parasites).
PRIME provides research services for third parties outsourced on a contract basis (i.e contract research organization). The experts in PRIME can be involved in project development, consultancy and rental of equipment. For more information you can contact the coordinator of PRIME, Wilma Janssen.
PRIME is a member of the pan-European Euro BioImaging project which will deploy a distributed biological and biomedical imaging infrastructure in Europa in a coordinated and harmonized manner. go to Euro BioImaging
PRIME joined the collaborative DTL platform of life science and technology research groups in the Dutch clinical & health, nutrition, crop and livestock breeding and industrial microbiology sectors. go to DTL platform
Publications in PRIMEAlexander S, Weigelin B, Winkler F, Friedl P (2013) Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response. Curr. Opin. Cell. Biol. Oct;25(5):659-71.
Wiesmann M, Zinnhardt B, Reinhardt D, Eligehausen S, Wachsmuth L, Hermann S, Dederen PJ, Hellwich M, Kuhlmann MT, Broersen LM, Heerschap A, Jacobs AH, Kiliaan AJ. A specific dietary intervention to restore brain structure and function after ischemic stroke. Theranostics. 2017 Jan 6;7(2):493-512ke.
Wiesmann M, Zerbi V, Jansen D, Haast R, Lütjohann D, Broersen LM, Heerschap A, Kiliaan AJ. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural Plast. 2016;2016:6846721.
Wiesmann M, Roelofs M, van der Lugt R, Heerschap A, Kiliaan AJ, Claassen JA. Angiotensin II, hypertension, and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan 1:271678X16667364se.
Haberl MG, Zerbi V, Veltien A, Ginger M, Heerschap A, Frick A. Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (-/y) mouse model of autism. Sci Adv. 2015 Nov 20;1(10):e1500775.
Heskamp S, Heijmen L, Gerrits D, Molkenboer-Kuenen JD, Ter Voert EG, Heinzmann K, Honess DJ, Smith DM, Griffiths JR, Doblas S, Sinkus R, Laverman P, Oyen WJ, Heerschap A, Boerman OC. Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases. Mol Imaging Biol. 2016 Oct 31.
Willekens SM, van der Kroon I, Bos D, Joosten L, Frielink C, Boerman OC, Brom M, Gotthardt M. Quantitative and longitudinal imaging of intramuscular transplanted islets of Langerhans with SPECT using [ 123 I]IBZM. Diabetes Obes Metab. 2017 Apr;19(4):604-608.
Steens SC, Bekers EM, Weijs WL, Litjens GJ, Veltien A, Maat A, van den Broek GB, van der Laak JA, Fütterer JJ, van der Kaa CA, Merkx MA, Takes RP. Evaluation of tongue squamous cell carcinoma resection margins using ex-vivo MR. Int J Comput Assist Radiol Surg. 2017 May;12(5):821-828.
Hoogenboom M, Eikelenboom D, den Brok MH, Veltien A, Wassink M, Wesseling P, Dumont E, Fütterer JJ, Adema GJ, Heerschap A. In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology. NMR Biomed. 2016 Jun;29(6):721-31.
Nunes PM, Wright AJ, Veltien A, van Asten JJ, Tack CJ, Jones JG, Heerschap A. Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice. FASEB J. 2014 May;28(5):1988-97.
Powerful techniques in biomedical research
All pre-clinical non-invasive imaging technologies available in PRIME are powerful techniques in biomedical research. Combining the strengths of anatomical and functional imaging modalities allows the detection and quantitative determination of morphological, physiological and metabolic processes.
Facility Intrinsic optical and multi-photon imaging
The combination of intrinsic optical imaging and multiphoton microscopy has many applications in neuroscience, because it allows to measure neural activity and structural changes in the nervous system at multiple scales.read more
PRIME is a partnership between the departments that provide dedicated state-of-the-art equipment and expertise.
- Nuclear Medicine
- Cell Biology
- Cognitive Neuroscience