PRIME Preclinical Imaging Center


Preclinical Imaging Center

PRIME is a centralized facility for multimodality imaging of small animals, such as mice and rats. Multi modality imaging is a strategic technology, that can be used to support biopharmaceutical development and preclinical research.

our aims and services

Preclinical Imaging Center

Aims

  • A durable facility for small animals imaging with state of the art equipment and expertise.
  • A facility with multi-modal equipment and offices integrated in one centre at one location.
  • A centre that operates essentially as a SPF/DMII unit to allow experiments with transgenic animals and with adeno, retro and lenti-viruses.
  • A centre with links to clinical/human imaging facilities.

Services

The infrastructure and imaging equipment in PRIME has some unique features under one roof in one facility:
  • State-of-the-art scanners for: MRI, SPECT, PET, optical imaging, multiphoton microscopy, intrinsic optical imaging and ultrasound.
  • Cognition and behavior rooms to measure (social) behavior  learning and memory  sensory-motor integration activity and  motor skills.
  • Barrier-free animal handling at safety level II allowing small animal studies with animals that can be infected with various agents (incl. adeno-/retroviruses, bacteria, parasites).

Contract

PRIME also supports the pharmaceutical and biotechnology industries in the form of research services outsourced on a contract basis. The experts of PRIME can be involved in project development and consultancy as well as giving explanations on the use of our equipment. For more information you can contact Wilma Janssen.

Contact

Wilma Janssen-Kessels
+31 (0)24 366 82 58
proces coördinator PRIME

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PRIME and ...

  • PRIME is a facility that provides support to the pharmaceutical and biotechnology industries in the form of research services outsourced on a contract basis. read more


    Contract Research Organization (CRO)

    The Preclinical Imaging Centre (PRIME) is a centralized facility for multimodality imaging of small animals, such as mice and rats. Multi modality imaging is a strategic technology, that can be used to support biopharmaceutical development and preclinical research.

    PRIME is staffed by experts from various disciplines such as Radiology, Nuclear Medicine, Cell Biology, Medical Ultrasound Imaging Center, Anatomy and Cognitive Neuroscience. The infrastructure and imaging equipment in PRIME has some unique features under one roof in one facility: 
    • state-of-the-art scanners for: MRI, SPECT, PET, optical imaging, multiphoton microscopy , intrinsic optical imaging and ultrasound.
    • cognition and behavior rooms to measure (social) behavior  learning and memory  sensory-motor integration activity and  motor skills.
    • barrier-free animal handling at safety level II allowing small animal studies with animals that can be infected with various agents (incl. adeno-/retroviruses, bacteria, parasites).
    Investigators from a wide range of research themes use the imaging facilities of PRIME e.g. Alzheimer, cancer development and immune defense, movement disorders, infectious diseases and host response, inflammatory diseases, urological cancers and women's cancers.

    PRIME provides research services for third parties outsourced on a contract basis (i.e contract research organization). The experts in PRIME can be involved in project development, consultancy and rental of equipment. For more information you can contact the coordinator of PRIME, Wilma Janssen.


Publications in PRIME

Alexander S, Weigelin B, Winkler F, Friedl P (2013) Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response. Curr. Opin. Cell. Biol. Oct;25(5):659-71.

Wiesmann M, Zinnhardt B, Reinhardt D, Eligehausen S, Wachsmuth L, Hermann S, Dederen PJ, Hellwich M, Kuhlmann MT, Broersen LM, Heerschap A, Jacobs AH, Kiliaan AJ. A specific dietary intervention to restore brain structure and function after ischemic stroke. Theranostics. 2017 Jan 6;7(2):493-512ke.

Wiesmann M, Zerbi V, Jansen D, Haast R, Lütjohann D, Broersen LM, Heerschap A, Kiliaan AJ. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural Plast. 2016;2016:6846721.

Wiesmann M, Roelofs M, van der Lugt R, Heerschap A, Kiliaan AJ, Claassen JA. Angiotensin II, hypertension, and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan 1:271678X16667364se.

Haberl MG, Zerbi V, Veltien A, Ginger M, Heerschap A, Frick A. Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (-/y) mouse model of autism. Sci Adv. 2015 Nov 20;1(10):e1500775.

Heskamp S, Heijmen L, Gerrits D, Molkenboer-Kuenen JD, Ter Voert EG, Heinzmann K, Honess DJ, Smith DM, Griffiths JR, Doblas S, Sinkus R, Laverman P, Oyen WJ, Heerschap A, Boerman OC. Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases. Mol Imaging Biol. 2016 Oct 31.

Willekens SM, van der Kroon I, Bos D, Joosten L, Frielink C, Boerman OC, Brom M, Gotthardt M. Quantitative and longitudinal imaging of intramuscular transplanted islets of Langerhans with SPECT using [ 123 I]IBZM. Diabetes Obes Metab. 2017 Apr;19(4):604-608.

Steens SC, Bekers EM, Weijs WL, Litjens GJ, Veltien A, Maat A, van den Broek GB, van der Laak JA, Fütterer JJ, van der Kaa CA, Merkx MA, Takes RP. Evaluation of tongue squamous cell carcinoma resection margins using ex-vivo MR. Int J Comput Assist Radiol Surg. 2017 May;12(5):821-828.

Hoogenboom M, Eikelenboom D, den Brok MH, Veltien A, Wassink M, Wesseling P, Dumont E, Fütterer JJ, Adema GJ, Heerschap A. In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology. NMR Biomed. 2016 Jun;29(6):721-31.

Nunes PM, Wright AJ, Veltien A, van Asten JJ, Tack CJ, Jones JG, Heerschap A. Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice. FASEB J. 2014 May;28(5):1988-97.

MRI scanner for mice

Less need for animal testing thanks to MRI scanner for mice.

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Imaging technologies


Powerful techniques in biomedical research

All pre-clinical non-invasive imaging technologies available in PRIME are powerful techniques in biomedical research. Combining the strengths of anatomical and functional imaging modalities allows the detection and quantitative determination of morphological, physiological and metabolic processes.


Facility MR imaging

An MR system uses a strong magnetic field to align the magnetization of some atoms in the body, and radio frequency fields to systematically alter this alignment for detection purposes.

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Facility Radionuclide imaging

Radionuclide imaging relies on the tracer principle in which a minute amount of a radioactive tracer is injected into the body to monitor a physiological/biochemical process.

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Facility Optical imaging

Optical imaging offers unique possibilities for in vitro and in vivo imaging applications, especially in the context of molecular imaging.

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Facility Ultrasound and photoacoustic imaging

High Frequency Ultrasound and Photoacoustic Imaging is a technique used to visualize detailed internal structures and function with unprecedented temporal and spatial resolution.

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Facility Multi-photon microscopy

Multi-photon excitation microscopy (MPM) is the approach of choice for fluorescence imaging of living three-dimensional tissue at subcellular resolution for up to one millimeter in depth.

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Facility Behavior and cognition

In the Behavior & Cognition Facilities, (social) behavior, cognition, sensory-motor integration and blood pressure in neural development, adolescence, ageing and neurodegenerative diseases can be measured in several mice models.

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Facility Intrinsic optical and multi-photon imaging

The combination of intrinsic optical imaging and multiphoton microscopy has many applications in neuroscience, because it allows to measure neural activity and structural changes in the nervous system at multiple scales.

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Facility Radiotherapy

With our XRad we can irradiate tumors in animals with varying doses. Our Physicists and technicians will determine the settings of the equipment and after that treatment with a dose varying from almost zero to >50Gy is possible.

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Getting there

Entrance: Animal Research Facility
Route: 231

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Getting there

Visiting address

PRIME
Geert Grooteplein 29
6525 EZ Nijmegen

Directions

Enter building at: Animal Research Facility
Follow route 231 (PRIME)

Team PRIME


Departments

PRIME is a partnership between the departments that provide dedicated state-of-the-art equipment and expertise.

  • Radiology
  • Nuclear Medicine
  • Cell Biology
  • Anatomy
  • Cognitive Neuroscience

Technology center Imaging

The Imaging Technology Center provides cutting-edge technology and service for imaging-related preclinical and clinical research questions. This covers the spectrum from molecule to man to population.

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Technology center Animal Research Facility

This technology center offers advice and support from planning up to and including the conduct of animal research on behalf of biomedical research and education.

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Technology center Microscopic Imaging Center

The Microscopic Imaging Center offers access to both standard and innovative advanced microscopy infrastructure and applications including technical operator-assistance and in-depth microscopic imaging knowledge.

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