Invasive fungal infections in influenza and COVID-198 July 2020
The Aspergillus fungus is found in the lungs of many COVID patients. A parallel occurs with influenza patients, who often develop a serious fungal infection. Although such a serious fungal infection seems to occur less frequently in COVID-patients, alertness remains necessary,
Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection29 June 2020
In a review in Cell Mihai Netea, Frank van de Veerdonk, Reinout van Crevel and Jorge Dominguez Andres propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.
New insight into the effect of hydroxychloroquine undermines its use in corona11 June 2020
Researchers at Radboud university medical center have discovered an as yet unknown effect of hydroxychloroquine. Raphael Duivenvoorden was interviewed in the program Op1 at NPO1 to elaborate on the findings. It seems unlikely that chloroquine has beneficial effect in corona infections.
Catecholamines induce trained immunity in monocytes in vitro and in vivo10 April 2020
Niels Riksen and colleagues contributed data in Circulation Research, to the understanding of pathways driving inflammatory changes in conditions characterized by high catecholamine levels, and proposed that trained immunity underlies the increased cardiovascular event rate in PHEO patients.
Study into better protection for healthcare workers against coronavirus infection19 March 2020
Radboudumc and UMC Utrecht will investigate whether health care workers are better protected against the coronavirus after a vaccination against tuberculosis (BCG vaccine). This vaccine does not directly protect against the coronavirus, but provides a boost to the immune system.
Interleukin-37 plays a rol in the pathogenesis and treatment of gout11 March 2020
RIMLS researchers Leo Joosten, Viola Klück and Rosanne van Deuren, in collaboration with the Dept. of Human Genetics, discovered that rare genetic variants in interleukin-37 link the anti-inflammatory cytokine to the pathogenesis and treatment of gout.
'Stofwisselkracht' grant for Paola de Haas and Alessandra Cambi5 December 2019
Paola de Haas and Alessandra Cambi, theme Nanomedicine, have recently been awarded a grant from ‘Stichting Stofwisselkracht’ for their project entitled “Identification of immune-related symptoms in Congenital Disorders of Glycosylation”.
Newly appointed Junior Principal Clinicians3 December 2019
The appointed junior Principal Clinician for RIMLS are Heidi Zweers-van Essen and Jenneke Leentjens. These caregivers are at the forefront of renewing patient care and take the lead in the development and realization of the Radboudumc vision.
Two RIHS researchers in top 1 percent by citations28 November 2019
Bart-Jan Kullberg and Jacques Meis, made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
Four Veni grants for junior RIMLS researchers22 July 2019
Four junior researchers, affiliated to the RIMLS, have each received a Veni grant of 250,000 Euro from NWO. Our researchers received this prestigious grant for their remarkable and original talent and their ability to carry out innovative research.
Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies18 June 2019
Exome sequencing may provide a genetic diagnosis in a significant number of patients in a single genetic test. Alexander Hoischen and Mihai Netea, theme Infectious diseases and global health, and colleagues, published their results in Genome Medicine.
Lowering cholesterol is not enough to reduce hyperactivity of the immune system14 June 2019
In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provide a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.
Removal of sialic acid from platelets responsible for thrombocytopenia in dengue23 April 2019
In the PLoS Pathogens Quirijn de Mast and his colleagues showed that excessive binding of the coagulation protein von Willebrand factor leads to removal of sialic acid from platelets and platelet clearance.
Interacting non-specific immunological effects of BCG and Tdapf vaccinations5 April 2019
In a randomized trial Mihai Netea and colleagues aim to investigate the non-specific immunological effects of BCG and DTP-containing vaccines on the immune response to unrelated pathogens. They have published their findings in Clinical Infectious Diseases.
Effect of prolonged antibiotic treatment on cognition in patients with Lyme borreliosis5 March 2019
In Neurology Anneleen Berende, Roy Kessels, Bart-Jan Kullberg and colleagues showed that longer-term antibiotic treatment did not lead to better cognitive performance compared to a 2-week regimen in patients with Lyme disease-attributed persistent symptoms.
15 million Euro to identify new drug targets for HIV28 February 2019
André van der Ven and Mihai Netea, theme Infectious diseases and global health, and colleagues, will receive 15 million Euro from pharmaceutical company ViiV Healthcare for research into new ways to fight the HIV virus. The aim of the HIV 2000+ project is to identify new drug targets for HIV.
Dekker grant for Siroon Bekkering28 January 2019
Siroon Bekkering, theme Vascular damage, obtained a Dekker grant of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'. And follow her vlog.
Five RIMLS researchers in top 1 percent by citations13 December 2018
Bas Dutilh, Leo Joosten, Jos van der Meer, Mihai Netea and Henk Stunnenberg made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
The itaconate pathway as a central regulatory node linking innate immune tolerance and trained immunity26 October 2018
Jorge Domínguez-Andrés and Mihai Netea demonstrate in Cell Metabolism, the importance of the IRG1-itaconate-SDH axis in the development of immune tolerance and trained immunity, and highlight the potential of β-glucan as a tool to revert immune paralysis induced by sepsis.