News items related to the Department of Internal Medicine.
Lowering cholesterol is not enough to reduce hyperactivity of the immune system14 June 2019
In Cell Metabolism, Siroon Bekkering, theme Vascular damage, and colleagues, provides a novel potential explanation for the residual cardiovascular risk, related to persistent activation of the immune system in patients with hypercholesterolemia who are treated with statins.
Removal of sialic acid from platelets responsible for thrombocytopenia in dengue23 April 2019
In the PLoS Pathogens Quirijn de Mast and his colleagues showed that excessive binding of the coagulation protein von Willebrand factor leads to removal of sialic acid from platelets and platelet clearance.
Interacting non-specific immunological effects of BCG and Tdapf vaccinations5 April 2019
In a randomized trial Mihai Netea and colleagues aim to investigate the non-specific immunological effects of BCG and DTP-containing vaccines on the immune response to unrelated pathogens. They have published their findings in Clinical Infectious Diseases.
Effect of prolonged antibiotic treatment on cognition in patients with Lyme borreliosis5 March 2019
In Neurology Anneleen Berende, Roy Kessels, Bart-Jan Kullberg and colleagues showed that longer-term antibiotic treatment did not lead to better cognitive performance compared to a 2-week regimen in patients with Lyme disease-attributed persistent symptoms.
15 million Euro to identify new drug targets for HIV28 February 2019
André van der Ven and Mihai Netea, theme Infectious diseases and global health, and colleagues, will receive 15 million Euro from pharmaceutical company ViiV Healthcare for research into new ways to fight the HIV virus. The aim of the HIV 2000+ project is to identify new drug targets for HIV.
Dekker grant for Siroon Bekkering28 January 2019
Siroon Bekkering, theme Vascular damage, obtained a Dekker grant of the Dutch Heart Foundation. This competitive grant allows Siroon to perform her project 'Trained innate immunity at the level of bone marrow progenitors as driver of atherosclerosis development'. And follow her vlog.
Five RIMLS researchers in top 1 percent by citations13 December 2018
Bas Dutilh, Leo Joosten, Jos van der Meer, Mihai Netea and Henk Stunnenberg made it to this year’s list of highly cited researchers. Researchers in this list are selected for their exceptional research performance and are regarded to have had a major impact on fellow scientists.
The itaconate pathway as a central regulatory node linking innate immune tolerance and trained immunity26 October 2018
Jorge Domínguez-Andrés and Mihai Netea demonstrate in Cell Metabolism, the importance of the IRG1-itaconate-SDH axis in the development of immune tolerance and trained immunity, and highlight the potential of β-glucan as a tool to revert immune paralysis induced by sepsis.